Palivizumab prophylaxis in infants with cystic fibrosis does not delay first isolation of Pseudomonas aeruginosa or Staphylococcus aureus

European Journal of Pediatrics
Clélia BuchsPhilippe Reix

Abstract

Respiratory syncytial virus (RSV) infections may worsen cystic fibrosis (CF) lung disease and favor Pseudomonas aeruginosa (Pa) or Staphylococcus aureus (Sa) acquisition, which is of particular importance in the youngest patients. We aimed to determine the effectiveness of PVZ on microbiological outcomes in young children with CF. We conducted a retrospective case-control study to compare these outcomes in children who systematically received PVZ (PVZ+; n = 40) or not (PVZ-; n = 140). One case was matched with at least three same-gender controls born the same year and month. Median (range) age at first Pa isolation was not statistically different between PVZ- (12.3 [3.8-32.6] months) and PVZ+ (10.4 [1.2-33.0] months; p = 0.953) patients. A similar trend was found for Sa (PVZ+: 6.4 [2.0-59.0] months; PVZ-: 3.8 [0.1-74.1] months; p = 0.191). The proportion of Pa isolations by 3 years of age did not differ between groups (PVZ+ 40% vs. PVZ- 41.4%), but this proportion was higher for Sa in the PVZ+ group (97%) than in the PVZ- group (85%; p = 0.001). Healthcare consumption and growth outcomes did not significantly differ between groups. Systematic PVZ use did not delay key pathogen acquisition in young children with CF. What is know...Continue Reading

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Citations

Jan 9, 2019·Frontiers in Immunology·Megan R Kiedrowski, Jennifer M Bomberger
Jul 3, 2021·Microorganisms·Gaspar A PachecoAlexis M Kalergis
Mar 4, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Ashley R DeschampStephanie D Davis
Jun 27, 2019·Pediatrics·Aliza K FinkLisa Saiman

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