Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

Organic & Biomolecular Chemistry
Harish K PotukuchiTimothy J Donohoe

Abstract

Aromatic heterocycles are a very well represented motif in natural products and have found various applications in chemistry and material science, as well as being commonly found in pharmaceutical agents. Thus, new and efficient routes towards this class of compound are always desirable, particularly if they expand the scope of chemical methodology or facilitate more effective pathways to complex substitution patterns. This perspective covers recent developments in the de novo synthesis of aromatic heterocycles via palladium-catalysed α-arylation reactions of carbonyls, which is itself a powerful transformation that has undergone significant development in recent years.

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Citations

Jan 23, 2016·Chemistry : a European Journal·Michael BrownThomas Wirth
Jun 30, 2015·Chemistry : a European Journal·Preston M MacQueenMark Stradiotto
Jun 19, 2015·Organic Letters·Leo A HardeggerTimothy J Donohoe
May 11, 2016·The Journal of Organic Chemistry·Liang HuGangguo Zhu
Jan 28, 2017·Organic & Biomolecular Chemistry·Dayun Huang, Guobing Yan
Apr 1, 2017·The Journal of Organic Chemistry·C Henrique Alves EstevesTimothy J Donohoe
Aug 8, 2019·Chemistry : a European Journal·Johannes C L WalkerTimothy J Donohoe
Jan 26, 2021·Chemical Communications : Chem Comm·Gaurav Saini, Manmohan Kapur
May 6, 2016·ACS Catalysis·Enrico MarelliSteven P Nolan
Jun 16, 2018·Organic Letters·C Henrique Alves EstevesTimothy J Donohoe
Mar 14, 2018·The Journal of Organic Chemistry·Gangam Srikanth KumarManmohan Kapur
Aug 19, 2021·The Journal of Organic Chemistry·Natarajan TamizharasanPalaniswamy Suresh
May 3, 2019·The Journal of Organic Chemistry·Xiangmeng ChenChau Ming So

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