Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp(3) )H and δ-CH Bonds with an Oxazoline-Carboxylate Auxiliary

Chemistry : a European Journal
Peng-Xiang LingBing-Feng Shi

Abstract

A palladium-catalyzed arylation of unactivated γ-methylene C(sp(3) )H and remote δ-CH bonds by using an oxazoline-carboxylate directing group has been developed. Arylation occurs with a broad substrate scope and high tolerance of functional groups (i.e., halogen, nitro, cyano, ether, trifluoromethyl, amine, and ester). The oxazoline-type auxiliary can be removed under acidic conditions.

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Citations

Aug 17, 2016·Journal of the American Chemical Society·Jing-Wen XuBing-Feng Shi
Nov 2, 2016·Journal of the American Chemical Society·Yongwei WuJin-Quan Yu
Dec 1, 2015·Chemistry : a European Journal·Chen WangYaofeng Chen
Oct 13, 2017·Chemistry : a European Journal·Soufyan JerhaouiFrançoise Colobert
Sep 21, 2018·Organic & Biomolecular Chemistry·Wei YiGong-Qing Liu
Oct 30, 2016·Chemistry : a European Journal·Soufyan JerhaouiFrançoise Colobert
Mar 24, 2016·Angewandte Chemie·Zhongxing HuangGuangbin Dong
Jun 8, 2021·Chemical Science·Jayabrata DasDebabrata Maiti
Dec 15, 2017·The Journal of Organic Chemistry·Charlotte E CoomberTom D Sheppard
Feb 18, 2020·Chemical Reviews·Aaron TrowbridgeMatthew J Gaunt
Jul 13, 2017·Chemical Reviews·Jian HeJin-Quan Yu

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