Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols

Organic Letters
Hong ZhangStephen L Buchwald

Abstract

Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions.

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Citations

Aug 30, 2019·Chemistry, an Asian Journal·Xiao-Xia MingCheng-Pan Zhang
Sep 3, 2019·Angewandte Chemie·Ruocheng SangTobias Ritter

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