Palladium catalyzed carbonylative Heck reaction affording monoprotected 1,3-ketoaldehydes

Organic Letters
Thomas M GøgsigTroels Skrydstrup

Abstract

The direct carbonylative palladium catalyzed synthesis of monoprotected 1,3-ketoaldehydes is reported starting from aryl iodides applying near stoichiometric amounts of carbon monoxide. Besides representing platforms for a variety of heterocyclic structures, these motives serve as viable precursors for the highly relevant aryl methyl ketones. The presented strategy can also be adapted for the facile and efficient incorporation of (13)C-labeled carbon monoxide.

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Citations

Feb 13, 2013·Journal of the American Chemical Society·Signe KorsagerTroels Skrydstrup
Sep 6, 2013·The Journal of Organic Chemistry·Andreas AhlburgTroels Skrydstrup
Feb 7, 2013·Organic Letters·Mia N BurhardtTroels Skrydstrup
Jun 13, 2014·The Journal of Organic Chemistry·Mia N BurhardtTroels Skrydstrup
Aug 11, 2016·The Journal of Organic Chemistry·Lodi Mahendar, Gedu Satyanarayana
Jun 3, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Dennis U NielsenTroels Skrydstrup
Nov 23, 2013·Chemistry : a European Journal·Dennis U NielsenTroels Skrydstrup
Sep 12, 2013·Chemistry : a European Journal·Johannes SchranckMatthias Beller
Sep 10, 2017·Nature Communications·Mikkel T JensenTroels Skrydstrup
May 1, 2018·Chemical Communications : Chem Comm·Pei-Sen GaoLi-Wen Xu
May 14, 2014·Organic Letters·Daniel R FandrickChris H Senanayake
May 24, 2019·Organic Letters·Hugo P CollinTroels Skrydstrup
Sep 30, 2020·Journal of the American Chemical Society·Dylan J ShieldsPanče Naumov

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