Palladium-Catalyzed Catellani ortho-Acylation Reaction: An Efficient and Regiospecific Synthesis of Diaryl Ketones

Angewandte Chemie
Yunze HuangZhenhua Gu

Abstract

A palladium-catalyzed, norbornene-mediated Catellani ortho-acylation reaction was developed by the use of either acyl chlorides or acid anhydrides as acylation reagents. The addition of more than a stoichiometric amount of H2 O is crucial for this transformation when acid chlorides are used, and kinetic studies indicate that the active acylation reagent is possibly an acid anhydride.

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Citations

Jun 23, 2016·Accounts of Chemical Research·Nicola Della Ca'Marta Catellani
Oct 8, 2016·Journal of the American Chemical Society·Peng WangJin-Quan Yu
Jan 7, 2017·Chemical Reviews·Dong-Su KimChul-Ho Jun
Jan 26, 2018·Angewandte Chemie·Hong-Gang ChengQianghui Zhou
Mar 21, 2018·Chemical Communications : Chem Comm·Ce LiuYong-Min Liang
May 5, 2016·Chemical Communications : Chem Comm·Jian HanYingsheng Zhao
Jul 12, 2018·Organic & Biomolecular Chemistry·Marcus WegmannThorsten Bach
Aug 7, 2018·Chemistry : a European Journal·Alessandra CasnatiTimothy Noël
Oct 23, 2015·Nature Chemistry·Juntao Ye, Mark Lautens
Jan 20, 2021·Organic Letters·Cui-Tian WangYong-Min Liang
Jul 13, 2021·Organic Letters·Ya-Nan DingYong-Min Liang
Apr 26, 2019·Chemical Reviews·Jianchun Wang, Guangbin Dong
Jun 16, 2018·Journal of the American Chemical Society·Zhe DongGuangbin Dong
Apr 3, 2020·Organic Letters·Alexander J Rago, Guangbin Dong
Jan 25, 2020·Journal of the American Chemical Society·Jianchun WangGuangbin Dong
Oct 23, 2019·Organic Letters·Si-Yi YangYong-Zheng Chen
Jul 11, 2018·Journal of the American Chemical Society·Nicholas A SerratoreChristopher J Douglas

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