Palladium-Catalyzed Intermolecular Aryliodination of Internal Alkynes

Angewandte Chemie
Yong Ho Lee, Bill Morandi

Abstract

A completely atom economical palladium-catalyzed addition reaction has been developed to stereoselectively access functionalized tetrasubstituted alkenyl iodides. The palladium catalyst, which bears an electron-poor bidentate ligand rarely employed in catalysis, is essential to promote the high yielding and chemoselective intermolecular reaction between equimolar amounts of an alkyne and an aryl iodide. This new carbohalogenation reaction is an attractive alternative to traditional synthetic methods, which rely on multistep synthetic sequences and protecting-group manipulations.

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Citations

Oct 22, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Axel StraubeEvamarie Hey-Hawkins
Mar 2, 2021·Angewandte Chemie·Austin D MarcheseMark Lautens
Aug 14, 2021·Journal of the American Chemical Society·Wufeng ChenChunming Cui
Nov 21, 2019·Journal of the American Chemical Society·Chenghao ZhuJunliang Zhang
Jul 25, 2020·Accounts of Chemical Research·Austin D MarcheseMark Lautens
Aug 26, 2021·Angewandte Chemie·Elliott H DentonBill Morandi
Oct 7, 2021·Chemistry : a European Journal·Finn J GeffersDaniel B Werz

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