Palladium-Catalyzed Intermolecular Heck-Type Dearomative [4 + 2] Annulation of 2H -Isoindole Derivatives with Internal Alkynes

Organic Letters
Tengfei YaoLu Liu

Abstract

Here, an interesting palladium-catalyzed intermolecular Heck-type dearomative [4 + 2] annulation of 2H-isoindole derivatives with internal alkynes has been developed, affording diverse polycyclic pyrrolidine scaffolds in good yield. This reaction is a useful method for the transformation of 2H-isoindole.

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