Palladium-catalyzed one-pot synthesis of 2-alkyl-2-arylcyanoacetates

The Journal of Organic Chemistry
Xiang WangMargaret M Faul

Abstract

A one-pot procedure for the synthesis of 2-alkyl-2-arylcyanoacetates based on a Pd(OAc)2/DPPF (DPPF = 1,1'-diphenylphosphino ferreocene)-catalyzed enolate arylation followed by in situ alkylation has been developed. This procedure tolerates a diverse range of aryl and heteroaryl bromides, and provides a rapid entry to a variety of 2-alkyl-2-arylcyanoacetates in good to excellent yield.

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Citations

Dec 4, 2015·Organic & Biomolecular Chemistry·Ben S PilgrimTimothy J Donohoe
Mar 20, 2015·Organic & Biomolecular Chemistry·Harish K PotukuchiTimothy J Donohoe
Nov 10, 2011·Organic Letters·Nick TodorovicAlfredo Capretta

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