Palladium-catalyzed one-pot synthesis of diazoles via tert-butyl isocyanide insertion

Organic & Biomolecular Chemistry
Xiang-Yuan FanYong-Ming Zhu

Abstract

An efficient one-pot palladium-catalyzed reaction for the synthesis of diazoles from readily available hydrazides and aryl halide via isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs diazoles in good to excellent yields with the advantages of wide functional group tolerance and operational simplicity.

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Citations

Jan 28, 2016·The Journal of Organic Chemistry·Zhen-Bang ChenJing-Kang Shen
Sep 15, 2017·Organic & Biomolecular Chemistry·Zhen-Bang ChenYong-Ming Zhu
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jurriën W ColletRomano V A Orru

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