Palladium-catalyzed one-step synthesis of isoindole-1,3-diones by carbonylative cyclization of o-halobenzoates and primary amines.

The Journal of Organic Chemistry
Shilpa A Worlikar, Richard C Larock

Abstract

The palladium-catalyzed aminocarbonylation of o-halobenzoates produces 2-substituted isoindole-1,3-diones in good yields. This methodology provides a good one-step approach to this important class of heterocycles and tolerates a variety of functional groups, including methoxy, alcohol, ketone, and nitro groups.

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Citations

Oct 9, 2012·Chemical Reviews·Xiao-Feng WuMatthias Beller
Jul 28, 2010·Angewandte Chemie·Jian ZhangSoon Hyeok Hong
Sep 10, 2014·Chemistry : a European Journal·Suman De Sarkar, Lutz Ackermann
Dec 5, 2012·Chemical Communications : Chem Comm·Ping-Xin ZhouYong-Min Liang
Nov 25, 2014·The Journal of Organic Chemistry·Huizhen LiuPaul J Dyson
Apr 25, 2014·The Journal of Organic Chemistry·Liliana Becerra-FigueroaDiego Gamba-Sánchez
Jan 27, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Margareta HorvatNikola Basarić
Jun 23, 2020·Beilstein Journal of Organic Chemistry·Margareta SohoraNikola Basarić
Oct 31, 2009·The Journal of Organic Chemistry·Wei Ren, Motoki Yamane
Mar 31, 2010·The Journal of Organic Chemistry·Wei Ren, Motoki Yamane
Feb 4, 2010·The Journal of Organic Chemistry·Marcin PtaszekJonathan S Lindsey
Jan 11, 2019·The Journal of Organic Chemistry·Yu-Chao YuanRafael Gramage-Doria
Aug 11, 2017·Journal of the American Chemical Society·Noel Angel Espinosa-JalapaDavid Milstein

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