Palladium-catalyzed oxidative C-H/C-H cross-coupling of 1-substituted 1,2,3-triazoles with furans and thiophenes

Organic & Biomolecular Chemistry
Xin YuChunXiang Kuang

Abstract

Palladium-catalyzed heteroarylation of 1-substituted 1,2,3-triazoles with furans and thiophenes has been developed in the presence of pyridine and Ag2CO3. The procedure is suitable for the regioselective preparation of 1,5-disubstituted 1,2,3-triazoles through conventional heating at reaction temperatures of 90-100 °C for 18 h.

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