Palladium-Catalyzed Oxidative Cycloisomerization of 2-Cinnamyl-1,3-Dicarbonyls: Synthesis of Functionalized 2-Benzyl Furans

Chemistry : a European Journal
Rajender NallagondaPrasanta Ghorai

Abstract

A new palladium-catalyzed intramolecular oxidative cycloisomerization of readily available starting materials, 2-cinnamyl-1,3-dicarbonyls, has been demonstrated for the creation of structurally diverse 2-benzyl furans. The cycloisomerization occurs by a regioselective 5-exo-trig pathway. The reaction shows a broad substrate scope with good to excellent yields. Furthermore, a one-pot procedure has been executed by using readily available cinnamyl alcohols and 1,3-diketones.

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Citations

Mar 3, 2017·The Journal of Organic Chemistry·Mohammad RehanPrasanta Ghorai
Jul 22, 2017·Organic & Biomolecular Chemistry·Wei-Ting LiuKun Zhang
Aug 22, 2017·Organic & Biomolecular Chemistry·Rajender NallagondaPrasanta Ghorai
Apr 17, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Jyoti RaiJeyaraman Sankar

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