Palladium-Catalyzed Sequential Acylation/Cyanation of Aryl Iodides: A Regiospecific Synthesis of 2-Cyanoaryl Ketones

The Journal of Organic Chemistry
Shanfei PanWanzhi Chen

Abstract

A palladium-catalyzed, norbornene-mediated acylation/cyanation reaction of iodobenzene was developed by the use of acyl chlorides as acylation reagents and cuprous cyanide. The reaction gave the 2-cyanoaryl ketones efficiently by using readily available starting materials.

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Citations

Jan 7, 2017·Chemical Reviews·Dong-Su KimChul-Ho Jun
Jan 26, 2018·Angewandte Chemie·Hong-Gang ChengQianghui Zhou
Mar 21, 2018·Chemical Communications : Chem Comm·Ce LiuYong-Min Liang
Jul 28, 2019·Chemical Communications : Chem Comm·Yong-Liang BanQiang Liu
Jan 20, 2021·Organic Letters·Cui-Tian WangYong-Min Liang
Apr 26, 2019·Chemical Reviews·Jianchun Wang, Guangbin Dong
Aug 8, 2019·Organic Letters·Zhenhua WangYasushi Nishihara
Jun 16, 2018·Journal of the American Chemical Society·Zhe DongGuangbin Dong

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