Palladium-Catalyzed Site-Selective C-H Functionalization of Weakly Coordinating Sulfonamides: Synthesis of Biaryl Sulfonamides

Chemistry, an Asian Journal
Rajeshwer VanjariKrishna Nand Singh

Abstract

A novel and site selective C-H functionalization of unsubstituted sulfonamides has been developed for the synthesis of ortho aryl sulfonamides. The reaction involves highly regioselective ortho mono arylation of weakly coordinating SO2 NH2 directing group by means of aryl iodides. Palladium acetate in the presence of silver(I) oxide is found to be the most effective catalytic system.

References

Jul 1, 1990·Journal of Medicinal Chemistry·C D SelassieT A Khwaja
Mar 17, 2000·Science·J Drews
Apr 8, 2003·Current Medicinal Chemistry·Andrea ScozzafavaClaudiu T Supuran
May 19, 2005·Journal of the American Chemical Society·Dipannita KalyaniMelanie S Sanford
May 25, 2005·Angewandte Chemie·Olafs Daugulis, Vladimir G Zaitsev
Aug 12, 2005·Organic Letters·Dmitry Shabashov, Olafs Daugulis
Mar 18, 2006·Angewandte Chemie·Lutz AckermannRobert Born
Jul 14, 2006·Chemical Reviews·Jean-Pierre Corbet, Gérard Mignani
Aug 16, 2006·Bioorganic & Medicinal Chemistry Letters·Zdzisław BrzozowskiNouri Neamati
Mar 6, 2007·Journal of the American Chemical Society·Ramesh GiriJin-Quan Yu
Apr 26, 2007·Journal of the American Chemical Society·Shangdong YangZhangjie Shi
Jul 26, 2007·Journal of the American Chemical Society·Hendrich A ChiongOlafs Daugulis
Sep 12, 2007·Journal of the American Chemical Society·Kami L Hull, Melanie S Sanford
Oct 7, 2008·Journal of the American Chemical Society·Ramesh Giri, Jin-Quan Yu
Dec 11, 2008·Journal of the American Chemical Society·Dong-Hui WangJin-Quan Yu
Jul 9, 2009·Organic Letters·Wing-Yiu YuAlbert S-C Chan
Jul 11, 2009·Angewandte Chemie·Yang-Hui ZhangJin-Quan Yu
Dec 4, 2009·Organic Letters·Chang-Liang SunZhang-Jie Shi
Jan 19, 2010·Chemical Reviews·Thomas W Lyons, Melanie S Sanford
Feb 11, 2010·Chemical Reviews·Petr SehnalIan J S Fairlamb
Jan 28, 2011·Journal of the American Chemical Society·Masanori KitaharaMasahiro Miura
Sep 8, 2011·Chemical Reviews·K C Majumdar, Shovan Mondal
Sep 15, 2011·Journal of the American Chemical Society·Keary M EngleJin-Quan Yu
Dec 15, 2011·Accounts of Chemical Research·Keary M EngleJin-Quan Yu
Mar 28, 2012·The Journal of Organic Chemistry·Dan-Dan LiGuan-Wu Wang
Sep 25, 2012·Angewandte Chemie·Manh V PhamNicolai Cramer
Jan 24, 2014·Chemical Communications : Chem Comm·Ravi Kiran Chinnagolla, Masilamani Jeganmohan
Jul 15, 2015·Journal of the American Chemical Society·Navid DastbaravardehJin-Quan Yu
Sep 18, 2015·Chemical Society Reviews·Rajeshwer Vanjari, Krishna Nand Singh
Jan 1, 1996·Journal of Research of the National Institute of Standards and Technology·David G Watson

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