Palladium-Catalyzed Synthesis of α-Iminonitriles from Aryl Halides via Isocyanide Double Insertion Reaction

The Journal of Organic Chemistry
Zhen-Bang ChenJing-Kang Shen

Abstract

An efficient one-pot synthesis of α-iminonitriles from readily available aryl halides via palladium-catalyzed double isocyanide insertion and elimination has been developed, without using various hypertoxic cyanides and excess oxidants. Furthermore, the utility of this reaction was demonstrated by the rapid total synthesis of quinoxaline and the reaction of functional groups exchanged with aryl halides.

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Citations

Apr 12, 2016·Chemistry : a European Journal·Fengxiang ZhuXiao-Feng Wu
May 17, 2018·Organic & Biomolecular Chemistry·Hongwei SunQiang Zhu
Sep 15, 2017·Organic & Biomolecular Chemistry·Zhen-Bang ChenYong-Ming Zhu
Nov 1, 2018·Organic & Biomolecular Chemistry·Zhengwang ChenMin Ye
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jurriën W ColletRomano V A Orru

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