Palladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic and photothermal therapy of prostate solid tumors

Colloids and Surfaces. B, Biointerfaces
Raj Kumar ThapaJong Oh Kim

Abstract

Intratumoral injection of nanoparticles is a viable alternative for treating solid tumors. In this study, we used intratumorally-injected palladium nanoparticle (Pd NP)-decorated graphene oxide (GO) (GO-Pd NPs) for the treatment of solid prostate tumors. GO was synthesized using the modified Hummer's method and GO-Pd NPs were prepared using the one pot synthesis method. Studies on physicochemical characterization and in vitro/in vivo anticancer properties were performed using GO-Pd NPs. Successful preparation of GO-Pd NPs was confirmed by transmission electron microscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Compared to GO or Pd NPs alone, GO-Pd NPs showed higher cytotoxic effects in prostate cancer 3 (PC3) cells. Irradiation of treated cells with near infrared (NIR) laser considerably enhanced apoptosis induced by synergistic photothermal effect and reactive oxygen species (ROS) generation. Intratumorally-injected GO-Pd NPs showed promising in vivo localized distribution, photothermal ablation, and anti-tumor effects in the PC3 xenograft mouse model. Furthermore, the minimal organ toxicity of GO-Pd NPs was an added advantage. Hence, GO-Pd NPs could...Continue Reading

Citations

Dec 15, 2019·Nanomaterials·Daniela Plachá, Josef Jampilek
Dec 16, 2018·International Journal of Molecular Sciences·Bartosz KlębowskiJarek Baran
Nov 19, 2019·Frontiers in Chemistry·Claudia FerroniGreta Varchi
Jan 2, 2020·Nanomaterials·Thi Tuong Vy PhanJunghwan Oh
Nov 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Weidong FeiCaihong Zheng
Jun 3, 2021·Materials·Filipa A L S SilvaArtur M Pinto
Dec 9, 2020·ACS Applied Materials & Interfaces·Kishwor PoudelJong Oh Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis