Palladium(II) complexes of NS donor ligands derived from steroidal thiosemicarbazones as antibacterial agents.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Abdullah M Asiri, Salman Ahmad Khan

Abstract

We have investigated the antibacterial activity of some new steroidal thiosemicarbazones and their Pd(II) metal complexes were prepared by the reaction of the thiosemicarbazones with [Pd(DMSO)(2)Cl(2)]. The steroidal thiosemicarbazones were prepared by the reaction of thiosemicarbazides with a steroidal ketone. The structures of these compounds were elucidated by IR, (1)H-NMR, (13)C-NMR, FAB mass spectroscopic methods, elemental analyses and TGA analysis. The antibacterial activity of these compounds were tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The results showed that steroidal complexes are better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) as compared to steroidal thiosemicarbazones. Compound Ia displays remarkable antibacterial activity as compared to amoxicillin.

References

Mar 18, 2003·Inorganic Chemistry·Parna GuptaSamaresh Bhattacharya
Nov 24, 2004·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sulekh Chandra, Umendra Kumar
Apr 29, 2008·European Journal of Medicinal Chemistry·Salman Ahmad KhanZaheer Khan
Sep 24, 2009·Bioorganic & Medicinal Chemistry·Karina S O FerrazHeloisa Beraldo

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