Palladium/phosphite-catalyzed 1,4-addition of arylboronic acids to acrylic acid derivatives

The Journal of Organic Chemistry
Hakaru HoriguchiMasahiro Miura

Abstract

1,4-Addition of arylboronic acids to acrylic acid derivatives proceeds efficiently in the presence of a palladium catalyst system of Pd(OAc)2/(PhO)3P to produce the corresponding 3-arylpropionic acid derivatives. The use of the phosphite ligand is the key to conducting the addition smoothly with suppressing the competing Mizoroki-Heck-type oxidative coupling.

References

Jan 9, 2003·Chemical Reviews·Keith Fagnou, Mark Lautens
Jun 21, 2003·Organic Letters·Young Chun JungKyung Woon Jung
Aug 14, 2003·Chemical Reviews·Tamio Hayashi, Kaori Yamasaki
Nov 5, 2005·Organic Letters·Francesca GiniAdriaan J Minnaard
Feb 15, 2007·Chemical Communications : Chem Comm·Tomoya Miura, Masahiro Murakami
Feb 21, 2007·The Journal of Organic Chemistry·Sawako MiyamuraMasahiro Miura

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