Palliative electro-chemotherapy in elderly patients with vulvar cancer: A phase II trial

Journal of Surgical Oncology
Anna Myriam PerronePierandrea De Iaco

Abstract

The primary endpoint of this trial was to assess clinical response (cCR) of squamocellular vulvar cancer (V-SCC) in elderly patients treated with electro-chemotherapy (ECT). Secondary endpoints were symptoms relief and local tumor control. A phase II study was designed and elderly patients with V-SCC unfit for other treatments were treated. Response Evaluation Criteria in Solid Tumors (RECIST criteria) were applied to evaluate tumor response. Quality of life (QoL) was evaluated by visual analogue score (VAS) for pain and four items of vulvar cancer subscale (VCS), of functional assessment of vulvar cancer therapy (FACT-V) [16], before, one month after the procedure and during follow-up. Median age was 85 years (range 66-96 years). One month after treatment complete response was observed in 13 patients (52%), partial response in 7 (28%), stable disease in 3 (12%), and progressive disease in 2 (8%). Local tumor control at 1 and 6 months was 91% and 53%, respectively. Symptom free survival at 1 and 6 months was 78% and 40%, respectively, with significant reduction of pain (P < 0.01). One-year overall survival was 34%. Our study showed that ECT produces high response rate with significant reduction of pain and improvement of local ...Continue Reading

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Citations

Jun 29, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Nicolò BizzarriPaolo Sala
Jun 8, 2018·Journal of Surgical Oncology·Anna M PerronePierandrea De Iaco
Dec 6, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anastasios TranoulisRahul Nath
Jun 1, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anna Myriam PerronePierandrea De Iaco
May 18, 2020·Cardiovascular and Interventional Radiology·F AndrescianiR F Grasso
May 7, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giacomo CorradoGiorgia Garganese
Jul 11, 2018·Technology in Cancer Research & Treatment·Ute ProbstPhilipp Wiggermann

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