Palliative endobronchial brachytherapy for non-small cell lung cancer

The Cochrane Database of Systematic Reviews
Andrés Felipe CardonaA Yepes

Abstract

Non-small cell lung cancers (NSCLC) constitutes about 80% of all lung cancer cases. Although surgery is the only curative treatment of NSCLC, fewer than 20% of tumors can be radically resected. Radiotherapy is one of the main treatment modalities in lung cancer, contributing to both its cure and palliation. Endobronchial brachytherapy (EBB) has been used as one approach to improve local control either alone or in combination with other treatments. To assess the effectiveness of palliative EBB in increasing survival and to control thoracic symptoms in patients with advanced NSCLC compared with external beam radiation therapy (EBRT) or other alternative endoluminal treatments. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and other databases were searched, as were reference lists and handsearching of selected journals and conference proceedings. Randomized controlled trials (RCTs) comparing different regimens of palliative EBB with EBRT or other endobronchial interventions in patients with advanced NSCLC. Thirteen RCTs were included. There were important differences in the doses of radiotherapy investigated, patient characteristics and the outcomes measured. Because of this heterogeneity no meta-an...Continue Reading

Citations

Nov 2, 2012·Clinical Medicine Insights. Oncology·Claribel P L SimmonsBarry J A Laird
Sep 17, 2011·Journal of Cancer Research and Clinical Oncology·Shengchu ZhangYunxiao Gao
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Ludovic ReveizAndrés Felipe Cardona

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