PMID: 8581393Oct 1, 1995Paper

Palliative radiation for stage 3 non-small cell lung cancer--a prospective study of two moderately high dose regimens

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
R P AbrattD G Salton

Abstract

Eighty four patients from Groote Schuur Hospital and Frere Hospital East London were entered into a prospective randomised trial between January 1990 and December 1993. All the patients possessed non-small cell carcinoma (NSCLC) of the lung too extensive for radical irradiation and World Health Organization performance status 0-2. The patients were randomised to receive either 35 Gy in 10 fractions (43 patients) or 45 Gy in 15 fractions (41 patients). In the patients treated to 35 Gy and 45 Gy, the median survival was 8.5 months in both groups, the symptomatic response rate was 68% and 76% and the incidence of moderate to severe radiation oesophagitis was 23% and 41% respectively. The latter approached statistical significance (P = 0.07, chi square). There was no evidence of a dose response effect on survival in the moderate dose range in patients treated palliatively for locally advanced NSCLC.

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Citations

Aug 22, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·W SharieffJ Wright
Apr 3, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K HayakawaH Niibe
Jun 8, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G NumicoM Merlano
May 16, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Raymond P AbrattAlistair Hunter
Mar 8, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F LonardiF Campostrini
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·R P Abratt
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Andrea BezjakUNKNOWN Clinical Trials Group of the National Cancer Institute of Canada
Apr 26, 2003·American Journal of Clinical Oncology·Elizabeth ToyAlison Eastwood
Oct 5, 2010·The Cancer Journal·Stephen LutzBenjamin Corn
Nov 2, 2012·Clinical Medicine Insights. Oncology·Claribel P L SimmonsBarry J A Laird
May 31, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C SchröderA Buchali
Dec 17, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Su K MetcalfeYuhchyau Chen
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Stein SundstrømUNKNOWN Norwegian Lung Cancer Study Group
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Gordon OkawaraUNKNOWN Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
Sep 26, 2003·Seminars in Surgical Oncology·Andrea Bezjak
Mar 3, 2007·Cancer·Stephen T LutzAndre A Konski
May 30, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cindy DuistersDirk De Ruysscher
Sep 13, 2002·Chest·Gerard A SilvestriAndrew Turrisi
Aug 3, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Marian ReinfussTeresa Kowalska
Apr 20, 2010·Expert Review of Anticancer Therapy·Lucyna Kepka, Marta Olszyna-Serementa
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alysa FairchildEdward Chow
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gijsbert W P M KramerJan-Willem H Leer
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A Bogart
Nov 24, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Wilfried Budach, Claus Belka

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