Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial

Cancer Medicine
Jeremy TeyJiade Lu

Abstract

To evaluate the response and quality of life of palliative gastric radiotherapy in patients with symptomatic locally advanced gastric cancer. Patients with bleeding, pain or obstruction and were treated with palliative gastric radiotherapy to a dose of 36 Gy in 12 daily fractions. The primary outcomes were symptom response rates. Secondary outcomes included overall survival, adverse events and proportion of patients with ≥10-point absolute improvement in the fatigue, nausea/vomiting and pain subscales in the EORTC Qualify of Life Questionnaire C30 (EORTC QLQ-C30) and dysphagia/pain subscales in the gastric specific module (STO22) at the end of RT and 1 month after the completion of radiotherapy. Fifty patients were accrued. Median survival duration was 85 days. 40/50 patients (80%) with bleeding, 2/2 (100%) patients with obstruction and 1/1 (100%) patient with pain responded to radiotherapy. Improvements fatigue, nausea/vomiting and pain subscales of the EORTC QLQ-C30 was seen in 50%, 28% and 44% of patients at the end of RT and in 63%, 31% and 50% of patients 1 month after RT. Improvements in dysphagia/pain subscales of the STO22 was seen in 42% and 28% of patients at then end of RT and 44% and 19% of patients 1 month after RT...Continue Reading

References

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Citations

Oct 8, 2019·British Journal of Hospital Medicine·Christopher Hughes, Ganesh Radhakrishna
May 2, 2020·The British Journal of Radiology·Osamu TanakaMasayuki Matsuo
Jul 28, 2019·Biomedicines·Hideaki KawabataShigehiro Motoi
Jan 11, 2020·Frontiers in Oncology·Zai LuoChen Huang
Oct 31, 2020·Annals of Surgical Oncology·Yinin HuVivian E Strong
May 4, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E OldenburgerK Haustermans

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT01341756

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