Palliative thoracic radiotherapy in lung cancer: An American Society for Radiation Oncology evidence-based clinical practice guideline

Practical Radiation Oncology
George RodriguesBenjamin Movsas

Abstract

To provide guidance to physicians and patients with regard to the use of external beam radiotherapy, endobronchial brachytherapy, and concurrent chemotherapy in the setting of palliative thoracic treatment for lung cancer, based on available evidence complemented by expert opinion. A Task Force authorized by the American Society for Radiation Oncology (ASTRO) Board of Directors synthesized and assessed evidence from 3 systematic reviews on the following topics: (1) dose fractionation in thoracic external beam radiotherapy (EBRT); (2) clinical utility of initial and salvage endobronchial brachytherapy (EBB); and (3) use of concurrent chemotherapy (CC) with palliative thoracic radiotherapy. Practice guideline recommendations were produced and are contained herein. Studies suggest that higher dose/fractionation palliative EBRT regimens (eg, 30 Gy/10 fraction equivalent or greater) are associated with modest improvements in survival and total symptom score, particularly in patients with good performance status. As these improvements are associated with an increase in esophageal toxicity, various shorter EBRT dose/fractionation schedules (eg, 20 Gy in 5 fractions, 17 Gy in 2 weekly fractions, 10 Gy in 1 fraction), which provide good...Continue Reading

References

May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·P TeoK H Tsui
Oct 1, 1995·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·R P AbrattD G Salton
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·G J ReesH F Newman
Jun 1, 1997·International Journal of Radiation Oncology, Biology, Physics·R M HuberT Wendt
Jul 14, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·B JeremicG Radosavljevic-Asic
Mar 4, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A ChellaC A Angeletti
Mar 7, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H LangendijkM Wouters
Oct 9, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Philip C HoffmanEverett E Vokes
Mar 10, 2004·Hematology/oncology Clinics of North America·Fergus Macbeth, Richard Stephens
Feb 18, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·S C ErridgeA Gregor
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gijsbert W P M KramerJan-Willem H Leer
Jul 26, 2006·Brachytherapy·Yee C UngUNKNOWN Lung Cancer Disease Site Group Of Cancer Care Ontario's Program In Evidence-Based Care
Dec 21, 2006·Journal of the National Cancer Institute·Wilbert B van den HoutJan-Willem H Leer
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tanguy Y SeiwertEverett E Vokes
Oct 3, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Vera HirshLuis Souhami
Feb 29, 2008·Cancer Chemotherapy and Pharmacology·Brian ChoiMinesh Mehta
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alysa FairchildEdward Chow
Nov 27, 2008·Journal of Medical Imaging and Radiation Oncology·J I TangM F Back
Jan 30, 2009·JAMA : the Journal of the American Medical Association·Allan D Sniderman, Curt D Furberg
Nov 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R SpigelF Anthony Greco
Apr 20, 2010·Expert Review of Anticancer Therapy·Lucyna Kepka, Marta Olszyna-Serementa

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Citations

May 23, 2014·Advances in Therapy·Patrick D Mitchell, Marcus P Kennedy
Nov 2, 2014·Seminars in Oncology Nursing·Erin McMenaminJoshua Jones
Nov 8, 2014·Lung India : Official Organ of Indian Chest Society·Navneet Singh, Digambar Behera
Dec 3, 2014·Revue de pneumologie clinique·S BellefqihN Benjaafar
Dec 17, 2014·Seminars in Oncology·Sonam SharmaJoshua Jones
May 31, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C SchröderA Buchali
Feb 14, 2016·Archivos de bronconeumología·Rosa CordovillaRafael Jiménez Merchán
Jun 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexander V LouieGeorge B Rodrigues
Mar 14, 2014·Practical Radiation Oncology·W Robert Lee
Jul 31, 2013·Journal of the American College of Radiology : JACR·Kenneth E RosenzweigHenning Willers
Sep 19, 2012·Seminars in Radiation Oncology·George Rodrigues, Michael Sanatani
Dec 25, 2015·International Journal of Radiation Oncology, Biology, Physics·William J Mackillop, Weidong Kong
Jul 22, 2014·CA: a Cancer Journal for Clinicians·Joshua A JonesPeter A Johnstone
Aug 14, 2015·Future Oncology·Kristopher DennisEdward Chow
Jan 18, 2015·Journal of Pain and Symptom Management·Mark J StavasEric T Shinohara
Oct 2, 2015·Journal of the National Cancer Institute·Matthew KoshyDavid J Sher
May 14, 2014·Journal of Pain and Symptom Management·Heidi N YeungJames D Murphy
Sep 4, 2015·Medical Physics·Frederick JungJohn C Roeske
Mar 29, 2014·Practical Radiation Oncology·Katherine Egan Bennett, W Robert Lee
Dec 9, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomasz WalasekPiotr Skotnicki
Oct 30, 2014·Frontiers in Oncology·Sergio L Faria
Oct 11, 2016·Journal of Pain and Symptom Management·David LiPaul K Maciejewski
Oct 14, 2016·European Journal of Cancer Care·N M RankinT Shaw
Jan 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aileen B ChenDeborah Schrag
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B Ashleigh GuadagnoloYa-Chen Tina Shih
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen T LutzEdward Chow
Jun 12, 2018·The British Journal of Radiology·Muhammad Shahid IqbalNicholas West
Jun 9, 2018·Expert Review of Respiratory Medicine·Christopher MallowLonny Yarmus
Dec 6, 2018·American Journal of Clinical Oncology·Neha P AminCharles B Simone
Apr 6, 2019·British Journal of Hospital Medicine·Simona GaitoGanesh Radhakrishna
Aug 5, 2014·Current Opinion in Supportive and Palliative Care·Patrick CheungGeorg A Bjarnason

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