Palliative treatment by high-dose-rate intraluminal brachytherapy in patients with advanced esophageal cancer

Brachytherapy
Janusz SkowronekGrzegorz Zwierzchowski

Abstract

The aim of this work was to analyze the results of palliative HDR brachytherapy in patients with advanced esophageal cancer. Ninety-one patients with unresectable, advanced esophageal cancer were treated palliatively by HDR brachytherapy. All patients received a total dose of 22.5 Gy in three fractions per week. Remissions of dysphagia and other clinical and radiological factors were assessed in the first month posttreatment, and then in the third, sixth, and twelfth months. The survival rate was compared with some chosen clinical factors using a log-rank test and the Kaplan-Meier method. The median survival time among all patients was 8.2 months. The median survival time according to the obtained remission was 14.6, 7.2, and 3.8 months (log-rank p = 00001, F Cox p = 0.00001) for complete remission (CR), partial remission (PR), and lack of remission (NR), respectively. A longer median survival time was observed when tumor size was less then 5 cm (12.1 months), than between 5 and 10 cm (7.8 months), or longer than 10 cm (6.4 months) (log-rank p = 0.002). Longer median survival times were observed in clinical stage II (14.1 months), compared with clinical stage III (7.7 months) and IV (7.2 months) (log-rank p = 0.01). Significant...Continue Reading

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Citations

Jun 5, 2008·Digestive Diseases and Sciences·Eduardo B da Silveira, Everson L Artifon
Oct 31, 2009·Brachytherapy·Maria Grazia FabriniLuca Cionini
Apr 22, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Á RovirosaS Rodríguez
May 17, 2017·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Seyed Mohsen Hosseini DaghighSeyed Rabi Mahdavi

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