Palliative treatment of metastatic bone pain with radiopharmaceuticals: A perspective beyond Strontium-89 and Samarium-153

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Francisco D C Guerra LiberalJoão Manuel R S Tavares

Abstract

The present review article aims to provide an overview of the available radionuclides for palliative treatment of bone metastases beyond (89)Sr and (153)Sm. In addition, it aims to review and summarize the clinical outcomes associated with the palliative treatment of bone metastases using different radiopharmaceuticals. A literature search was conducted on Science Direct and PubMed databases (1990 - 2015). The following search terms were combined in order to obtain relevant results: "bone", "metastases", "palliative", "care", "therapy", "treatment", "radiotherapy", "review", "radiopharmaceutical", "phosphorus-32", "strontium-89", "yttrium-90", "tin-117m", "samarium-153", "holmium-166", "thulium-170", "lutetium-177", "rhenium-186", "rhenium-188" and "radium-223". Studies were included if they provided information regarding the clinical outcomes. A comparative analysis of the measured therapeutic response of different radiopharmaceuticals, based on previously published data, suggests that there is a lack of substantial differences in palliative efficacy among radiopharmaceuticals. However, when the comparative analysis adds factors such as patient's life expectancy, radionuclides' physical characteristics (e.g. tissue penetration...Continue Reading

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Citations

May 18, 2016·Cancer Biotherapy & Radiopharmaceuticals·Madhava B MalliaSharmila Banerjee
Feb 12, 2020·International Journal of Radiation Biology·Hesham M H ZakalyMichael Zhukovsky
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Oct 7, 2020·International Journal of Radiation Biology·Roger W Howell
Jun 9, 2021·Nuklearmedizin. Nuclear Medicine·Hassan Ranjbar, Zahra Pourhabib

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