Pallidal and thalamic deep brain stimulation in myoclonus-dystonia

Movement Disorders : Official Journal of the Movement Disorder Society
Doreen GruberAndreas Kupsch

Abstract

Deep brain stimulation (DBS) of the internal globus pallidus (GPi) and ventral intermediate thalamic nucleus (VIM) are established treatment options in primary dystonia and tremor syndromes and have been reported anecdotally to be efficacious in myoclonus-dystonia (MD). We investigated short- and long-term effects on motor function, cognition, affective state, and quality of life (QoL) of GPi- and VIM-DBS in MD. Ten MD-patients (nine epsilon-sarcoglycan-mutation-positive) were evaluated pre- and post-surgically following continuous bilateral GPi- and VIM-DBS at four time points: presurgical, 6, 12, and as a last follow-up at a mean of 62.3 months postsurgically, and in OFF-, GPi-, VIM-, and GPi-VIM-DBS conditions by validated motor [unified myoclonus rating scale (UMRS), TSUI Score, Burke-Fahn-Marsden dystonia rating scale (BFMDRS)], cognitive, affective, and QoL-scores. MD-symptoms significantly improved at 6 months post-surgery (UMRS: 61.5%, TSUI Score: 36.5%, BFMDRS: 47.3%). Beneficial effects were sustained at long-term evaluation post-surgery (UMRS: 65.5%, TSUI Score: 35.1%, BFMDRS: 48.2%). QoL was significantly ameliorated; affective status and cognition remained unchanged postsurgically irrespective of the stimulation co...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Sep 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·M S Lee, C D Marsden
Mar 20, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·P LimousinM Janssens
Nov 30, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·A KupschT Funk
Feb 17, 2000·The New England Journal of Medicine·P R SchuurmanJ D Speelman
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·B P BejjaniY Agid
Mar 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·T TrottenbergA Kupsch
Aug 2, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·T TrottenbergA Kupsch
Mar 12, 2002·Pediatric Pulmonology·T Zimmermann
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Xuguang LiuJohn F Stein
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackJerry Vitek
Sep 27, 2002·Annals of Neurology·Friedrich AsmusThomas Gasser
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Dec 4, 2003·Parkinsonism & Related Disorders·J D PutzkeR J Uitti
Mar 24, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Cameron C McIntyreJerrold L Vitek
May 4, 2004·Parkinsonism & Related Disorders·Martin Parent, André Parent
Jun 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Laura CifPhilippe Coubes
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Feb 4, 2005·The New England Journal of Medicine·Marie VidailhetUNKNOWN French Stimulation du Pallidum Interne dans la Dystonie (SPIDY) Study Group
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·C M Magariños-AsconeR Figueiras-Méndez
Nov 4, 2005·Neurology·S SagarB F Boeve
Nov 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·T D HälbigA Kupsch
May 24, 2006·Neurology·B PillonUNKNOWN French SPIDY Study Group
Oct 13, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·E GripsJ C Wöhrle
Nov 10, 2006·The New England Journal of Medicine·Andreas KupschUNKNOWN Deep-Brain Stimulation for Dystonia Study Group
Jan 12, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Elisabeth M J FonckeMarina A J Tijssen
Feb 17, 2007·Lancet Neurology·Marie VidailhetUNKNOWN French SPIDY Study Group
May 23, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Jürgen VogesMarkus O Pinsker
Aug 4, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Matthew O HebbIvar Mendez
Sep 14, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Nardo NardocciBarbara Garavaglia
Oct 2, 2007·Brain : a Journal of Neurology·Zelma H T KissUNKNOWN Canadian Movement Disorders Group
Nov 2, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Joerg MuellerUNKNOWN Deep-Brain Stimulation for Dystonia Study Group
Nov 6, 2007·Journal of Neurosurgery·Chikashi FukayaTakamitsu Yamamoto
Jan 22, 2008·Human Mutation·A GrünewaldC Klein
Dec 11, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·K RitzM A J Tijssen
Jan 2, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Kiyoka KinugawaEmmanuel Roze
Feb 12, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E MoroA M Lozano
Apr 15, 2009·Archives of Neurology·Ioannis U IsaiasMichele Tagliati
May 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Mandar Jog, Hrishikesh Kumar

❮ Previous
Next ❯

Citations

Apr 2, 2011·Current Treatment Options in Neurology·Naomi Lubarr, Susan Bressman
Feb 1, 2013·Brain : a Journal of Neurology·Kathryn J PeallHuw R Morris
Nov 17, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Marie VidailhetEmmanuel Roze
Oct 8, 2013·Journal of Neurosurgery. Pediatrics·Melita T PetrossianNutan Sharma
Apr 10, 2014·Case Reports in Neurological Medicine·Akinori UruhaRyoichi Okiyama
Nov 1, 2011·Expert Opinion on Medical Diagnostics·Stefania LalliAlberto Albanese
Jan 27, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Helena RochaRui Vaz
May 1, 2013·Progress in Neurobiology·Christiane WoopenLars Timmermann
Aug 2, 2011·Basal Ganglia·Thomas Wichmann, Mahlon R Delong
Mar 10, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Wichmann, Mahlon R DeLong
Jun 30, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Kathryn J PeallHuw R Morris
Feb 13, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Anand I Rughani, Andres M Lozano
Jun 24, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Andreas KupschJoachim K Krauss
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Laurie J OzeliusSusan B Bressman
Jul 31, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Alberto AlbaneseAnette Schrag
Nov 11, 2015·Nature Reviews. Neurology·Rodi ZuttMarina A Tijssen
Mar 13, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Ji Hee KimJin Woo Chang
Mar 20, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Emmanuel RozeDavid Grabli
Jul 27, 2015·Parkinsonism & Related Disorders·K J PeallM A J Tijssen
Apr 3, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·J J FitzGeraldT Z Aziz
May 9, 2014·Parkinsonism & Related Disorders·Christos SidiropoulosAnthony E Lang
Jun 16, 2016·Lancet Neurology·Anne KoyLars Timmermann
Jun 3, 2016·Expert Review of Neurotherapeutics·Lazzaro di Biase, Renato Puppi Munhoz
Oct 4, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Laura Cif, Philippe Coubes
Apr 8, 2016·Neurologia Medico-chirurgica·Hiroki TodaKoichi Iwasaki
Nov 16, 2014·Current Neurology and Neuroscience Reports·Kelly Mills, Zoltan Mari
Jun 12, 2013·Journal of Child Neurology·Debabrata Ghosh, Shalaka Indulkar
Jan 24, 2014·Journal of Child Neurology·Andrea A KühnGerd-Helge Schneider
May 22, 2018·Expert Review of Neurotherapeutics·Rubens Gisbert CuryElena Moro
Aug 12, 2017·Movement Disorders Clinical Practice·René Reese, Jens Volkmann
Aug 27, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Elisa MenozziKailash P Bhatia
May 23, 2012·Current Opinion in Neurology·Alberto Albanese, Stefania Lalli
May 23, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Dávid PintérNorbert Kovács
Jul 3, 2013·Current Opinion in Neurology·Suneil K KaliaAndres M Lozano
Aug 24, 2017·Der Nervenarzt·J Rémi, K Bötzel
Oct 9, 2018·Frontiers in Computational Neuroscience·Terence D Sanger
Oct 12, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Zuzana KosutzkaMarie Vidailhet
Sep 11, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ashley B Pena, John N Caviness
May 28, 2019·Frontiers in Neurology·Stephanie CerneraAysegul Gunduz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.