Pallidal border cells: an anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey

Neuroscience
E BezardC Gross

Abstract

A dopamine transporter-radioligand binding study demonstrated a dopaminergic innervation around the pallidal complex in the normal monkey (n=5), i.e. where a subpopulation of pallidal neurons known as "border cells" is classically identified. Surprisingly, this peripallidal binding persists in monkeys rendered parkinsonian (n=5) with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment. The border cell electrophysiological activity was then analysed in normal and parkinsonian monkeys (n=2), either in the untreated state or following administration of levodopa. Pallidal border cell firing frequency was significantly decreased after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment (8.9+/-0.7 vs 31.4+/-1.6Hz, P<0.05). This decrease was partly corrected by levodopa administration (19.2+/-1.0Hz, P<0.05 vs both normal and parkinsonian situations). The peripallidal dopaminergic innervation suggests that pallidal border cells are under a direct dopaminergic control, arising from the ventral tegmental area and/or the basal forebrain magnocellular complex, the role of which remains unknown. Moreover, the relative sparing of these dopaminergic fibers in parkinsonian monkeys suggests that they would exhibit specific adaptive proper...Continue Reading

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Citations

May 3, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Thomas J FeuersteinAndreas Moser
Apr 23, 2010·Science Translational Medicine·Mohamed R AhmedErwan Bezard
Jan 16, 2014·Neurobiology of Learning and Memory·Rudy Schreiber, Adrian Newman-Tancredi
Dec 3, 2014·Biological Psychiatry·Matthieu F BastideErwan Bézard
May 17, 2008·CNS Neuroscience & Therapeutics·Patrick EmondSylvie Chalon
Jul 20, 2005·Brain Research. Brain Research Reviews·Milind Deogaonkar, Thyagarajan Subramanian
Jun 26, 2004·The European Journal of Neuroscience·Elsa DiguetFrançois Tison
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erwan BezardJonathan M Brotchie
Mar 5, 2003·Journal of Neurochemistry·Christian E GrossErwan Bezard
Dec 5, 2008·Journal of Neurophysiology·Mati JoshuaHagai Bergman

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