PMID: 9164690May 1, 1997Paper

Pallidotomy increases cortical inhibition in Parkinson's disease

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
A StrafellaA E Lang

Abstract

Pallidotomy helps parkinsonian symptoms. We tested the hypothesis that this might be due to changes in inhibition in the motor cortex. We examined 15 patients with parkinsonism before and after posteroventral pallidotomy. Magnetic stimuli were delivered over the motor cortex, while subjects maintained a 30% maximum voluntary contraction of the contralateral first dorsal interosseus (FDI). Weak stimuli inhibited voluntary muscle activity, while slightly stronger stimuli caused short latency facilitation from activation of the corticospinal neurons. After pallidotomy magnetic stimulation, at the threshold for the short latency facilitation, resulted in more inhibition than before. Pallidotomy increases cortical inhibition. This may be associated with improved control of movements.

References

Jul 1, 1990·Trends in Neurosciences·M R DeLong
Jan 1, 1992·Journal of Neurosurgery·L V LaitinenM I Hariz
Nov 25, 1995·Lancet·A M LozanoJ O Dostrovsky
Nov 1, 1993·The Journal of Physiology·T KujiraiC D Marsden

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Citations

Feb 9, 1999·Journal of Neurosurgery·D KondziolkaL D Lunsford
Feb 24, 2001·Nuclear Medicine Communications·K van LaereR Dierckx
Nov 27, 2002·Journal of Neurosurgery·Sergio CanaveroPaola Ragazzi
Dec 14, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Chon-Haw TsaiHsiu-Chen Chang

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