Palmar hyperlinearity in early childhood atopic dermatitis is associated with filaggrin mutation and sensitization to egg

Pediatric Dermatology
Tatsuki FukuieYoshiki Tokura

Abstract

Palmar hyperlinearity is a typical clinical feature of Filaggrin gene (FLG) null mutations. There are reports of FLG mutations and allergic sensitization; however, reports on the relationship between palmar hyperlinearity to sensitization are limited. This study aimed to examine the association between palmar hyperlinearity and sensitization in atopic dermatitis (AD) children. This cross-sectional, case-control study included children ˂ 6 years old with moderate-severe AD whose parents consented for mutation analysis and photographic documentation. Each child underwent genotyping to detect the eight most prevalent FLG mutations in the Japanese population: R501X, 3321delA, S1695X, Q1701X, S2554X, S2889X, S3296X, and K4022X. Clinical features and parameters including egg-specific IgE were examined, and palm photographs were evaluated by 12 trained dermatologists blinded to genotyping results. Of the 57 patients (age range, 2 months to 5 years; median, 22 months), 16 were heterozygotes and three were compound heterozygotes. Palmar hyperlinearity, as recognized by more than two-thirds of dermatologists, was significantly associated with FLG mutation (P = 0.002, OR = 6.98, 95% CI = 2.1-23.7), and this association was observed especi...Continue Reading

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Citations

Oct 18, 2019·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Catherine Drislane, Alan D Irvine
Jul 7, 2021·Immunology and Allergy Clinics of North America·Kanwaljit K Brar
Aug 5, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Yoshiki Tokura, Satoshi Hayano

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