Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Xiao-Jun ZhangJian-Nan Chen

Abstract

Inflammatory bowel disease (IBD), majorly include Crohn's disease (CD) and ulcerative colitis (UC), is chronic and relapsing inflammatory disorders of the gastrointestinal tract, which treatment options remain limited. Here we examined the therapeutic effects of an isoquinoline alkaloid, Palmatine (Pal), on mice experimental colitis induced by dextran sulfate sodium (DSS) and explored underlying mechanisms. Colitis was induced in BALB/c mice by administering 3% DSS in drinking water for 7 days. Pal (50 and 100 mg kg-1) and the positive drug Sulfasalazine (SASP, 200 mg kg-1) were orally administered for 7 days. Disease activity index (DAI) was evaluated on day 8, and colonic tissues were collected for biochemistry analysis. The fecal microbiota was characterized by high-throughput Illumina MiSeq sequencing. And plasma metabolic changes were detected by UPLC-MS. Our results showed that Pal treatment significantly reduced DAI scores and ameliorated colonic injury in mice with DSS-induced colitis. Mucosal integrity was improved and cell apoptosis was inhibited. Moreover, gut microbiota analysis showed that mice received Pal-treatment have higher relative abundance of Bacteroidetes and Firmicutes, but reduced amount of Proteobacteri...Continue Reading

Citations

Sep 10, 2019·Phytotherapy Research : PTR·Dominik Tarabasz, Wirginia Kukula-Koch
Jul 31, 2020·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Mar 21, 2020·Scientific Reports·Lijuan LiuWei Xiong
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Haojie YangZhenyi Wang
Oct 29, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yao LiXiaohui Zheng
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wanghui JingHaitao Lu
Jun 18, 2021·World Journal of Gastroenterology : WJG·Xin WenXiao-Zhong Yang
Jul 14, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiao-Xiao LiClara Bik-San Lau
Aug 3, 2021·Frontiers in Pharmacology·Linshan DuanGuoyan Liu
Aug 4, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mei-Mei WuXiao-Jun Zhang
Oct 27, 2021·Molecular Nutrition & Food Research·Yan GengZheng-Hong Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis