Palmerolide A, a cytotoxic macrolide from the antarctic tunicate Synoicum adareanum

Journal of the American Chemical Society
Thushara DiyabalanageBill J Baker

Abstract

Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 muM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase.

Citations

Jun 25, 2013·European Journal of Medicinal Chemistry·Bin YuHong-Min Liu
Mar 26, 2011·Chemical Reviews·Giovanni CasiraghiFranca Zanardi
Apr 27, 2007·Journal of the American Chemical Society·Xin JiangJef K De Brabander
Nov 28, 2007·Journal of Natural Products·Yoshinari MiyataBill J Baker
Jul 27, 2007·Natural Product Reports·Matthew D LebarBill J Baker
Nov 23, 2007·Natural Product Reports·Neil DixonJason Micklefield
Feb 6, 2008·Natural Product Reports·John W BluntMichèle R Prinsep
Oct 22, 2009·Natural Product Reports·Sean F BradyEric W Schmidt
May 12, 2011·Integrative and Comparative Biology·James B McClintockBill J Baker
Dec 9, 2010·Marine Drugs·Yoel KashmanMaurice Aknin
Sep 3, 2011·Future Medicinal Chemistry·Rana Montaser, Hendrik Luesch
Aug 22, 2013·Natural Product Research·Desaraju SmithaDesaraju Venkata Rao
Mar 23, 2017·Natural Product Reports·Sylvia Soldatou, Bill J Baker
Dec 30, 2014·Medicinal Research Reviews·Carrie WatermanBill J Baker
Oct 4, 2012·Chemistry : a European Journal·Amit B Pawar, Kavirayani R Prasad
Oct 4, 2012·Chemistry : a European Journal·Gordon J Florence, Joanna Wlochal
Oct 3, 2018·Marine Drugs·Lei ChenGuang-Yu Wang
Jun 30, 2007·Angewandte Chemie·K C NicolaouDavid Y-K Chen
Jan 30, 2009·Natural Product Reports·Jonathan C Morris, Andrew J Phillips
Jan 30, 2009·Natural Product Reports·John W BluntMichèle R Prinsep
May 8, 2009·Organic & Biomolecular Chemistry·Jennifer E MathiesonRodolfo Marquez
May 14, 2010·Natural Product Reports·Jörn Piel
Dec 25, 2012·Natural Product Reports·John W BluntMichèle R Prinsep
Aug 28, 2015·Archives of Pharmacal Research·Hye-Dong YooMin-Sun Kim
Jul 22, 2020·Organic & Biomolecular Chemistry·Ashik A SayyadKrishna P Kaliappan
Mar 1, 2017·Marine Drugs·Yuan TianFeng-Chun Zhao
May 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Cameron R PyeRoger G Linington
Aug 6, 2020·Marine Drugs·Laura Núñez-PonsDaniela Giordano
Sep 14, 2011·Chemistry, an Asian Journal·Sandip A PujariKrishna P Kaliappan
Jul 2, 2020·Marine Drugs·Joe BracegirdleRobert A Keyzers
Apr 17, 2010·Chemistry : a European Journal·Parthasarathy GowrisankarKrishna P Kaliappan
Nov 20, 2013·Chemistry : a European Journal·Marilda P Lisboa, Gregory B Dudley
Apr 23, 2015·Angewandte Chemie·Yong-Qiang ZhangAndreas Gansäuer
Jan 27, 2021·Journal of Natural Products·Joe BracegirdleRobert A Keyzers
Mar 5, 2021·Natural Product Reports·Weicheng Zhang

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