Palmitate induces lipoapoptosis in Schwann cells through ROS generation-mediated STAMP2 downregulation

Biochemical and Biophysical Research Communications
Sung Won LeeYoung Hyun Yoo

Abstract

Free fatty acids (FFAs) are considered the principal inducers of lipotoxicity, leading to cell dysfunction and/or cell death. Lipotoxicity in Schwann cells (SCs) damages neurons, which may be associated with peripheral neuropathies and axon degeneration. However, the molecular mechanism by which FFAs exert lipotoxicity in SCs remains to be established. In the present study, we demonstrate that palmitate exerts lipotoxicity in SCs through apoptosis and that palmitate-induced lipotoxicity in SCs is mediated through reactive oxygen species (ROS) generation. We observed that the six-transmembrane protein of prostate 2 (STAMP2), which plays a pivotal role in lipid homeostasis, is expressed in SCs. We further demonstrate that palmitate induces lipoapoptosis in SCs through ROS generation-mediated STAMP2 downregulation and that STAMP2 depletion accelerates the palmitate-exerted lipoapoptosis in SCs, indicating that STAMP2 confers on SCs the ability to resist palmitate-induced lipotoxicity. In conclusion, palmitate induces lipoapoptosis in SCs through ROS generation-mediated STAMP2 downregulation. Our findings indicate that ROS and STAMP2 may represent suitable targets for pharmacological interventions targeting lipotoxicity-associated ...Continue Reading

Citations

Jul 3, 2019·Journal of Cellular Biochemistry·Huiyan ZhangXuezhong Liu
Dec 10, 2019·Current Opinion in Lipidology·Kenneth J Mukamal
Sep 24, 2020·Journal of the American Geriatrics Society·Peter AhiawodziKenneth J Mukamal
Nov 15, 2020·Basic Research in Cardiology·Mehreen BatoolHenrik Ten Freyhaus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis