Palmitoylation as a Functional Regulator of Neurotransmitter Receptors

Neural Plasticity
Vladimir S Naumenko, Evgeni Ponimaskin

Abstract

The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions. One of these modifications is a covalent attachment of a 16-C palmitic acid to one or more cysteine residues (S-palmitoylation) within the target protein. Palmitoylation is a reversible modification, and repeated cycles of palmitoylation/depalmitoylation might be critically involved in the regulation of multiple signaling processes. Palmitoylation also represents a common posttranslational modification of the neurotransmitter receptors, including G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LICs). From the functional point of view, palmitoylation affects a wide span of neurotransmitter receptors activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, recycling, and synaptic clustering. This review summarizes the current knowledge on the palmitoylation of neurotransmitter receptors and its role in the regulation of receptors functions as well as in the control of different kinds of physiological and pathological behavior.

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Citations

Jun 15, 2020·Developmental Psychobiology·Stacey N DoanJerrold S Meyer
Jan 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Oksana A Sergeeva, F Gisou van der Goot
Mar 13, 2020·The Journal of Biological Chemistry·Yanling PanTheodore R Cummins
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Dec 11, 2020·Life Sciences·Ailin YangHaoyan Wang
Jan 21, 2020·Neuropharmacology·Philippe De DeurwaerdèreGiuseppe Di Giovanni
Dec 10, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Chansik HongInsuk So
Jan 13, 2021·Molecular Brain·Benjun Ji, Małgorzata Skup
Apr 22, 2021·Brain Structure & Function·Nicole KerkenbergWeiqi Zhang
Apr 8, 2021·Applied Spectroscopy·Ziyu YangMeiping Zhao
Jul 3, 2021·International Journal of Molecular Sciences·Monika Zaręba-KoziołJakub Włodarczyk
Mar 27, 2019·Journal of Chemical Theory and Computation·Riccardo CapelliMichele Parrinello
Mar 24, 2020·The Journal of Physical Chemistry. B·Stefan Gahbauer, Rainer A Böckmann
Aug 7, 2021·The European Journal of Neuroscience·Nicole KerkenbergChrista Hohoff
Sep 25, 2021·Journal of Neuroscience Research·Jade DegrandmaisonLouis Gendron

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Methods Mentioned

BETA
glycosylation
lipidation

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