Palmoplantar keratodermas: clinical and genetic aspects

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Cristina Has, Kristin Technau-Hafsi

Abstract

Palmoplantar keratodermas comprise a diverse group of acquired and hereditary disorders marked by excessive thickening of the epidermis of palms and soles. Early onset and positive family history suggest a genetic cause. While hereditary forms of palmoplantar keratoderma (PPK) may represent the sole or dominant clinical feature, they may also be associated with other ectodermal defects or extracutaneous manifestations. In recent years, much progress has been made in deciphering the genetic basis of PPK, which has led to the emergence of new disorders and syndromes. The elucidation of disease mechanisms has opened new avenues for specific therapies, increasingly sparking interest in this field. Given the high heterogeneity with respect to clinical features, genetic defects, and disease mechanisms, the classification of PPK is based on various criteria. These include extent of disease manifestations, morphology of palmoplantar skin involvement, inheritance patterns, and molecular pathogenesis. Though not always feasible, the clinical distinction of various PPK entities is based on fine-tuned criteria or clues. Remarkably, apparently distinct disorders have been shown to be allelic, as they are caused by mutations in the same gene...Continue Reading

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Citations

Aug 16, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·S KhalilM Kurban
Mar 1, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·L GuerraG Zambruno
Feb 6, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·L GuerraG Zambruno
Oct 28, 2017·Journal of the American Podiatric Medical Association·Rebecca M PorterFrances J D Smith
Sep 18, 2018·The British Journal of Dermatology·C Has
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Apr 30, 2020·Genes·Katherine A BackelElizabeth A Mauldin
Oct 21, 2020·F1000Research·Catherine Baker, Matthew S Hayden
Mar 4, 2021·Biomedicines·Dragan CopicMichael Mildner

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