Palonosetron Versus Ramosetron Prophylaxis for Control of Postoperative Nausea and Vomiting after Cesarean Delivery under Spinal Anesthesia

Journal of Obstetrics and Gynaecology of India
Suman Chattopadhyay, Sebanti Goswami

Abstract

Postoperative nausea and vomiting (PONV) after spinal anesthesia for cesarean delivery are distressing to both patients and surgeons. This study was designed to evaluate the efficacy and safety of palonosetron and ramosetron (both newer and highly potent 5HT3 receptor antagonists) in nausea and vomiting in cesarean delivery after spinal anesthesia. In this randomized, double-blind study, 109 women received either palonosetron (0.075 mg) or ramosetron (0.3 mg) intravenously immediately after clamping of the fetal umbilical cord. Nausea, vomiting, adverse events, and overall satisfaction were then observed for 48 h after administration of spinal anesthesia. A complete response (defined as no postoperative nausea and vomiting) during first 0-2 h postoperative after administration of spinal anesthesia was achieved in 85.5 % of patients with palonosetron and in 83.3 % of patients with ramosetron (p > 0.05). However, the corresponding incidence during 2 to 24 h was 70.9 and 53.7 %, respectively (p < 0.05), while it was 63.3 and 44.4 % at 24-48 h after anesthesia (p < 0.05). Along with a more complete response, the severity of nausea was also lesser with palonosetron during the corresponding study periods (2-24 and 24-48 h, respective...Continue Reading

References

Nov 24, 2011·Anesthesiology Research and Practice·S ChatterjeeS Sengupta
Dec 22, 2011·British Journal of Anaesthesia·A Chandrakantan, P S A Glass
Aug 2, 2013·Journal of Obstetrics and Gynaecology of India·Mandira DasguptaManash Bhanja Chowdhury
Dec 21, 2013·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia

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Citations

Aug 25, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chao XiongAnshi Wu
Oct 1, 2016·Journal of Clinical Anesthesia·Preet Mohinder SinghBasavana Goudra
May 19, 2021·The Cochrane Database of Systematic Reviews·James D GriffithsJane Thomas

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