Abstract
PAMAM dendrimers form host-guest complexes with 8-methoxypsoralene (8-MOP) - the photosensitizer for PUVA therapy. The stoichiometry of complexes was studied by (1)H NMR spectroscopy in solution and by differential scanning calorimetry in neat mixtures containing 8-MOP and dendrimers of generations G2.5, G3, G3.5, and G4. The dendrimers showed solubilization effect for 8-MOP resulting in increase of 8-MOP concentration in methanol up to 15 molecules of 8-MOP per G2.5 and G3 and 30 molecules of 8-MOP per G3.5, and G4. Isolation of oily host-guest complexes containing 3 or 7 molecules of 8-MOP per G3 and G4, respectively corroborate well with DSC results; glass transition temperature of neat host-guest complexes increases with number of host molecules in comparison with G3 or G4, until the capacity of host is exceeded. The oily host-guest complexes of stoichiometry 3:1 and 7:1 of 8-MOP to G3 and G4, respectively are well soluble in water. The 3:1 host-guest complexes diffused slowly through polyvinyldifluoride and pig ear skin membranes, when released from o/w emulsion. The host-guest complex 8-MOP-G3 was proposed as convenient formulation for psoralene skin administration in PUVA therapy.
References
Apr 10, 1997·The New England Journal of Medicine·R S SternL H Väkevä
Jun 6, 2003·International Journal of Pharmaceutics·Parag KolheMary Lieh-Lai
Dec 29, 2004·Journal of Drug Targeting·Abhay Singh ChauhanAjay Jaysingh Khopade
Jun 17, 2005·Cancer Research·Jolanta F Kukowska-LatalloJames R Baker
Aug 16, 2005·International Journal of Pharmaceutics·Aristarchos PapagiannarosCostas Demetzos
Oct 20, 2005·Journal of Bioscience and Bioengineering·Zhixiong WangKiyohito Yagi
Nov 29, 2005·Advanced Drug Delivery Reviews·Antony D'Emanuele, David Attwood
Dec 16, 2005·AAPS PharmSciTech·Abhay AsthanaNarendra Kumar Jain
Jun 26, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jia-You FangYu-Han Su
Nov 4, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sonke Svenson
Citations
May 25, 2012·Biomacromolecules·Yang YangSeungpyo Hong
Sep 14, 2012·International Journal of Nanomedicine·A Filipowicz, S Wołowiec
Jan 1, 2014·International Journal of Nanomedicine·Łukasz UramStanisław Wołowiec
Feb 19, 2013·Advanced Drug Delivery Reviews·Serge MignaniJean-Pierre Majoral
Jul 8, 2015·Expert Opinion on Therapeutic Patents·Jiepin YangYiyun Cheng
Jun 15, 2013·Drug Delivery·Yang ChenLiang Fang
Jan 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohiuddin A Quadir, Rainer Haag
Aug 2, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Aanchal GhaiAnil Kumar Mishra
Apr 22, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Srinivas MutalikHarendra S Parekh
Aug 14, 2012·International Journal of Pharmaceutics·Katarzyna BorowskaSebastian Radej
Feb 7, 2012·Pharmaceutical Development and Technology·Lin GuFang Jiao
Jun 22, 2015·Journal of Molecular Graphics & Modelling·Reinaldo G BelliniBruno A C Horta
Jul 16, 2011·Journal of Pharmaceutical and Biomedical Analysis·Veronika BiricováPetr Hermann
Jan 29, 2011·International Journal of Pharmaceutics·A Filipowicz, S Wołowiec
Jan 1, 2014·International Journal of Pharmaceutics·Marian JędrychBarbara Jodłowska-Jędrych
Feb 9, 2012·International Journal of Pharmaceutics·Katarzyna BorowskaSebastian Radej
Dec 18, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A LaznickovaP Hermann
May 3, 2015·Carbohydrate Polymers·Xiaole QiZhenghong Wu
Jul 29, 2017·Advanced Materials·Rong YangDaniel S Kohane
Oct 11, 2019·Dermatologic Therapy·Giovanni DamianiNicola L Bragazzi
Mar 7, 2021·International Journal of Molecular Sciences·Aleksandra KaczorowskaKatarzyna Borowska
Apr 11, 2017·Talanta·Dandan GuoYan Zhu
Apr 11, 2012·Chemical Reviews·Jingjing HuYiyun Cheng