PAMAM dendrimers as solubilizers and hosts for 8-methoxypsoralene enabling transdermal diffusion of the guest

International Journal of Pharmaceutics
Katarzyna BorowskaStanisław Wołowiec

Abstract

PAMAM dendrimers form host-guest complexes with 8-methoxypsoralene (8-MOP) - the photosensitizer for PUVA therapy. The stoichiometry of complexes was studied by (1)H NMR spectroscopy in solution and by differential scanning calorimetry in neat mixtures containing 8-MOP and dendrimers of generations G2.5, G3, G3.5, and G4. The dendrimers showed solubilization effect for 8-MOP resulting in increase of 8-MOP concentration in methanol up to 15 molecules of 8-MOP per G2.5 and G3 and 30 molecules of 8-MOP per G3.5, and G4. Isolation of oily host-guest complexes containing 3 or 7 molecules of 8-MOP per G3 and G4, respectively corroborate well with DSC results; glass transition temperature of neat host-guest complexes increases with number of host molecules in comparison with G3 or G4, until the capacity of host is exceeded. The oily host-guest complexes of stoichiometry 3:1 and 7:1 of 8-MOP to G3 and G4, respectively are well soluble in water. The 3:1 host-guest complexes diffused slowly through polyvinyldifluoride and pig ear skin membranes, when released from o/w emulsion. The host-guest complex 8-MOP-G3 was proposed as convenient formulation for psoralene skin administration in PUVA therapy.

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Citations

Sep 14, 2012·International Journal of Nanomedicine·A Filipowicz, S Wołowiec
Jan 1, 2014·International Journal of Nanomedicine·Łukasz UramStanisław Wołowiec
Jul 8, 2015·Expert Opinion on Therapeutic Patents·Jiepin YangYiyun Cheng
Jan 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohiuddin A Quadir, Rainer Haag
Aug 2, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Aanchal GhaiAnil Kumar Mishra
Apr 22, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Srinivas MutalikHarendra S Parekh
Aug 14, 2012·International Journal of Pharmaceutics·Katarzyna BorowskaSebastian Radej
Jun 22, 2015·Journal of Molecular Graphics & Modelling·Reinaldo G BelliniBruno A C Horta
Jan 29, 2011·International Journal of Pharmaceutics·A Filipowicz, S Wołowiec
Feb 9, 2012·International Journal of Pharmaceutics·Katarzyna BorowskaSebastian Radej
Dec 18, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A LaznickovaP Hermann
Jul 29, 2017·Advanced Materials·Rong YangDaniel S Kohane
Oct 11, 2019·Dermatologic Therapy·Giovanni DamianiNicola L Bragazzi
Mar 7, 2021·International Journal of Molecular Sciences·Aleksandra KaczorowskaKatarzyna Borowska
Apr 11, 2012·Chemical Reviews·Jingjing HuYiyun Cheng

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