PMID: 16509531Mar 3, 2006Paper

Pamidronate treatment of polyostotic fibrous dysplasia: failure to prevent expansion of dysplastic lesions during childhood

Journal of Pediatric Endocrinology & Metabolism : JPEM
Brendan Chan, Margaret Zacharin

Abstract

To examine outcomes of pamidronate treatment on fibrous dysplasia of bone in three children with McCune-Albright syndrome (MAS). Radiological evidence of fibrous dysplasia progress was reviewed for three children with MAS who were treated with pamidronate from age 2.5-5 years, for 8-10.5 years. Despite minimal pain and a low fracture rate in long bones, except where gross deformity exists, all dysplastic lesions present in long bones continued to undergo uncontrolled expansion. In contrast, there were no major new changes in facial configuration, no clinically obvious expansion of sphenoid wing lesions and no encroachment on optic foramina or visual field restriction in any patient. Despite previous reports of limitation or reduction in size of fibrous dysplasia lesions in adults and children, it is our experience that bisphosphonate treatment of polyostotic fibrous dysplasia in children with MAS does not arrest the expanding nature of these lesions.

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Citations

May 21, 2008·Orphanet Journal of Rare Diseases·Claudia E Dumitrescu, Michael T Collins
Jun 1, 2012·Orphanet Journal of Rare Diseases·J S LeeL B Kaban
Mar 31, 2011·Journal of Clinical Research in Pediatric Endocrinology·Zehra AycanSemra Çetinkaya
Jan 7, 2014·Calcified Tissue International·Malissa Dawn Thomsen, Lars Rejnmark
Apr 26, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Isabella SaggioMara Riminucci
Jul 22, 2008·The Journal of Pediatrics·Anurag BajpaiMargaret Zacharin
Apr 1, 2009·Current Therapeutic Research, Clinical and Experimental·Muriel S Parisi, Beatriz Oliveri
Sep 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bas Cj MajoorNeveen At Hamdy
May 23, 2014·Journal of Molecular Endocrinology·Kyle TurcicRobin Pals-Rylaarsdam
Jul 13, 2017·Clinical Endocrinology·Sze Choong Wong, Margaret Zacharin
Mar 6, 2018·Journal of Paediatrics and Child Health·Peter J SimmUNKNOWN APEG Bone Mineral Working Group
Nov 2, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yabing WangXiaoping Xing
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Jul 6, 2020·Bone·Marie-Francoise HeymannDominique Heymann

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