Abstract
Some children with cerebral palsy (CP) have frequent fractures due to low bone mineral density and receive treatment with pamidronate, an intravenous bisphosphonate. Our review evaluates the outcome of pamidronate treatment in these children. A retrospective chart review was performed, and 32 patients (14 girls and 18 boys) with CP Gross Motor Function Classification System level III (2 patients), IV (3 patients), and V (27 patients) treated with 5 courses of pamidronate for low mineral density were identified. Patients with a minimum of 2 years of follow-up were included in the study. Data collection was a review of the demographics and pretreatment, peritreatment, and posttreatment fracture history. The mean age at treatment was 11.6 years (range, 2.9 to 19.6 y). There were 102 fractures (mean duration 2.5 y) pretreatment and 28 fractures posttreatment. With an average follow-up of 6.4 years, posttreatment rate of fracture decreased to 0.10 fractures per year from the pretreatment rate of 2.4 fractures per year (P<0.001). The femur was the most common bone fractured both pretreatment (54%) and posttreatment (61%); the major site was the distal third of the femur. There were 11 fractures during the course of pamidronate treatm...Continue Reading
References
Apr 1, 1977·The Journal of Clinical Endocrinology and Metabolism·W JubizK G Tolman
Mar 1, 1991·Journal of Pediatric Orthopedics·J A Dent, C R Paterson
Nov 1, 1995·The Journal of Bone and Joint Surgery. American Volume·R C HendersonW B Greene
Jul 7, 1999·The Journal of Pediatrics·K E ChadR E Snyder
Feb 19, 2002·Developmental Medicine and Child Neurology·F BischofJ M Pettifor
Nov 1, 2002·The Journal of Pediatrics·Richard C HendersonSteven J Bachrach
Apr 24, 2003·Pediatric Radiology·Leslie E Grissom, H Theodore Harcke
Aug 2, 2003·The New England Journal of Medicine·Michael P WhyteSteven Mumm
Oct 26, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E MarxVishtasb Broumand
Aug 26, 2006·Journal of Pediatric Orthopedics·Arabella I LeetPaul D Sponseller
Nov 23, 2006·Pediatric Rehabilitation·Richard D StevensonRichard C Henderson
Feb 23, 2007·Journal of Pediatric Orthopedics·Ana PresedoFreeman Miller
Apr 15, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nesibe AndiranNursen Yordam
May 2, 2008·Journal of Orthopaedic Trauma·Andrew S NeviaserDean G Lorich
Nov 4, 2009·The Journal of Bone and Joint Surgery. American Volume·Craig M Capeci, Nirmal C Tejwani
Dec 19, 2009·Clinical Orthopaedics and Related Research·Katerina CermakMichael J Gebhart
Jun 25, 2010·Developmental Medicine and Child Neurology·Steven J BachrachJobayer Hossain
Feb 26, 2011·Clinical Orthopaedics and Related Research·Michael B BanffyJohn A Abraham
Aug 31, 2011·Pediatric Radiology·H Theodore HarckeLeslie E Grissom
Nov 30, 2011·Clinical Orthopaedics and Related Research·William G WardCynthia L Emory
Mar 2, 2013·Journal of Children's Orthopaedics·N NicolaouM J Bell
Jun 12, 2013·Clinical Oral Investigations·Petra RuganiStephan Acham
Citations
Feb 20, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S TrivediP J Tebben
Sep 17, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Rose M KreikemeierEric T Rush
Mar 6, 2018·Journal of Paediatrics and Child Health·Peter J SimmUNKNOWN APEG Bone Mineral Working Group
Nov 20, 2016·Journal of Pediatric Orthopedics·John A HeydemannJulieanne P Sees
Jun 10, 2020·Clinical Obstetrics and Gynecology·Rebecca J Gordon, Catherine M Gordon
Dec 17, 2018·Calcified Tissue International·Arnaud WiedemannFrançois Feillet
Jul 21, 2016·Developmental Medicine and Child Neurology·Sezgi OzelDarcy Fehlings
Dec 4, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N NasomyontH Wasserman
Feb 20, 2021·Clinical Epidemiology·Daniel G WhitneyMichelle S Caird
Jul 6, 2021·The Cochrane Database of Systematic Reviews·Tim HurleyEleanor Molloy