Pamidronate Treatment to Prevent Reoccurring Fractures in Children With Cerebral Palsy

Journal of Pediatric Orthopedics
Julieanne P SeesFreeman Miller

Abstract

Some children with cerebral palsy (CP) have frequent fractures due to low bone mineral density and receive treatment with pamidronate, an intravenous bisphosphonate. Our review evaluates the outcome of pamidronate treatment in these children. A retrospective chart review was performed, and 32 patients (14 girls and 18 boys) with CP Gross Motor Function Classification System level III (2 patients), IV (3 patients), and V (27 patients) treated with 5 courses of pamidronate for low mineral density were identified. Patients with a minimum of 2 years of follow-up were included in the study. Data collection was a review of the demographics and pretreatment, peritreatment, and posttreatment fracture history. The mean age at treatment was 11.6 years (range, 2.9 to 19.6 y). There were 102 fractures (mean duration 2.5 y) pretreatment and 28 fractures posttreatment. With an average follow-up of 6.4 years, posttreatment rate of fracture decreased to 0.10 fractures per year from the pretreatment rate of 2.4 fractures per year (P<0.001). The femur was the most common bone fractured both pretreatment (54%) and posttreatment (61%); the major site was the distal third of the femur. There were 11 fractures during the course of pamidronate treatm...Continue Reading

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Citations

Feb 20, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S TrivediP J Tebben
Sep 17, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Rose M KreikemeierEric T Rush
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Nov 20, 2016·Journal of Pediatric Orthopedics·John A HeydemannJulieanne P Sees
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Jul 6, 2021·The Cochrane Database of Systematic Reviews·Tim HurleyEleanor Molloy

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