Mar 20, 2020

Pan-cancer analysis identified inflamed microenvironment associated multi-omics signatures

bioRxiv
Ben WangYunsheng Ou

Abstract

Background: Immunotherapy has revolutionized cancer therapy. However, responses are not universal. The inflamed tumor microenvironment has been reported to correlate with response in tumor patients. However, how different tumors shape their tumor microenvironment remains a critical unsolved problem. A deeper insight into the molecular characteristics of inflamed tumor microenvironment may be needed. Materials and methods: Here, based on single-cell RNA sequencing technology and TCGA pan-cancer cohort, we investigated multi-omics molecular features of tumor microenvironment phenotypes. Based on single-cell RNA-seq analysis, we classified pan-cancer tumor samples into inflamed or non-inflamed tumor and identified molecular features of these tumors. Analysis of integrating identified gene signatures with a drug-genomic perturbation database identified multiple drugs which may be helpful for converting non-inflamed tumors to inflamed tumors. Results: Our results revealed several inflamed/non-inflamed tumor microenvironments-specific molecular characteristics. For example, inflamed tumors highly expressed miR-650 and lncRNA including MIR155HG and LINC00426, these tumors showed activated cytokines-related signaling pathways. Interest...Continue Reading

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Mentioned in this Paper

MIR155HG gene
Problem
Promoter
LINC00426 gene
Signal Pathways
RNA, Long Untranslated
Inflammation
RNA
Pharmacologic Substance
Genes

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