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Pan-Cancer Analysis of Mutation Hotspots in Protein Domains

Cell Systems

Sep 23, 2015

Martin L MillerChris Sander

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Abstract

In cancer genomics, recurrence of mutations in independent tumor samples is a strong indicator of functional impact. However, rare functional mutations can escape detection by recurrence analysis owing to lack of statistical power. We enhance statistical power by extending the notion of...read more

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    • References42
    • Citations14
    • References42
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  • Pan-Cancer Analysis of Mutation Hotspots in Protein Domains

    Cell Systems

    Sep 23, 2015

    Martin L MillerChris Sander

    PMID: 27135912

    DOI: 10.1016/j.cels.2015.08.014

    Abstract

    In cancer genomics, recurrence of mutations in independent tumor samples is a strong indicator of functional impact. However, rare functional mutations can escape detection by recurrence analysis owing to lack of statistical power. We enhance statistical power by extending the notion of...read more

    38
    1
    178
    Paper Details
    References
    • References42
    • Citations14
    • References42
    • Citations14
  • Get paper from

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