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Pan-Cancer Analysis of Mutation Hotspots in Protein Domains

Cell Systems

May 3, 2016

Martin L MillerChris Sander

Abstract

In cancer genomics, recurrence of mutations in independent tumor samples is a strong indicator of functional impact. However, rare functional mutations can escape detection by recurrence analysis owing to lack of statistical power. We enhance statistical power by extending the notion of...read more

Mentioned in this Paper

Genes
Neoplasms
Recurrent Malignant Neoplasm
Genomics
Cell Growth
Recurrence (Disease Attribute)
Genetic Hotspot
Protein Domain
Analysis
Malignant Neoplasms
38
1
181
Paper Details
References
  • References42
  • Citations21
12345
  • References42
  • Citations21
123

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Pan-Cancer Analysis of Mutation Hotspots in Protein Domains

Cell Systems

May 3, 2016

Martin L MillerChris Sander

PMID: 27135912

DOI: 10.1016/j.cels.2015.08.014

Abstract

In cancer genomics, recurrence of mutations in independent tumor samples is a strong indicator of functional impact. However, rare functional mutations can escape detection by recurrence analysis owing to lack of statistical power. We enhance statistical power by extending the notion of...read more

Mentioned in this Paper

Genes
Neoplasms
Recurrent Malignant Neoplasm
Genomics
Cell Growth
Recurrence (Disease Attribute)
Genetic Hotspot
Protein Domain
Analysis
Malignant Neoplasms
38
1
181

Similar Papers Found In These Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.

Related Papers

Nucleic Acids Research

MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer

Nucleic Acids ResearchNovember 22, 2015
Nicholas Paul GauthierMartin L Miller
Methods of Biochemical Analysis

Creation and analysis of protein multiple sequence alignments

Methods of Biochemical AnalysisJuly 14, 2001
G J Barton
Paper Details
References
  • References42
  • Citations21
12345
  • References42
  • Citations21
123
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