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Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion

Frontiers in Immunology

Nov 12, 2019

Yingcheng WuRenfang Mao

Abstract

Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved. Here, we systematically analyze the core genes of the circadian clock (CLOCK, ARNTL, ARNTL2, NPAS2, NR1D1, NR1D2, CRY1, CRY2, R...read more

Mentioned in this Paper

Biochemical Pathway
Immune Evasion
T-Lymphocyte
PER2 protein, human
PER3 protein, human
Gene Deletion
RORA protein, human
Programmed Cell Death Protein 1
Aryl Hydrocarbon Receptor Nuclear Translocator-like 2 Protein
CLOCK
3
4
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Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion

Frontiers in Immunology

Nov 12, 2019

Yingcheng WuRenfang Mao

PMID: 31708917

DOI: 10.3389/fimmu.2019.02451

Abstract

Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved. Here, we systematically analyze the core genes of the circadian clock (CLOCK, ARNTL, ARNTL2, NPAS2, NR1D1, NR1D2, CRY1, CRY2, R...read more

Mentioned in this Paper

Biochemical Pathway
Immune Evasion
T-Lymphocyte
PER2 protein, human
PER3 protein, human
Gene Deletion
RORA protein, human
Programmed Cell Death Protein 1
Aryl Hydrocarbon Receptor Nuclear Translocator-like 2 Protein
CLOCK
3
4

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Tumor Evasion of the Immune System

Tumor evasion of the immune system includes cells that operate their own growth and develop various strategies to escape from immune surveillance. Discover the latest research on tumor evasion of the immune system here.

T cells: Costimulatory Receptors

T cell activation requires engagement of both the T cell receptor and a co-stimulatory molecule. Lack of a co-stimulatory signal can result in T cell anergy, deletion, or immune tolerance. Find the latest research on T cell co-stimulatory receptors here.

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Paper Details
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