Pan-Cancer Immunogenomic Perspective on the Tumor Microenvironment Based on PD-L1 and CD8 T-Cell Infiltration

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Chan-Young OckDae Seog Heo

Abstract

There is currently no reliable biomarker to predict who would benefit from anti-PD-1/PD-L1 inhibitors. We comprehensively analyzed the immunogenomic properties in The Cancer Genome Atlas (TCGA) according to the classification of tumor into four groups based on PD-L1 status and tumor-infiltrating lymphocyte recruitment (TIL), a combination that has been suggested to be a theoretically reliable biomarker of anti-PD-1/PD-L1 inhibitors. The RNA expression levels of PD-L1 and CD8A in the samples in the pan-cancer database of TCGA (N = 9,677) were analyzed. Based on their median values, the samples were classified into four tumor microenvironment immune types (TMIT). The mutational profiles, PD-L1 amplification, and viral association of the samples were compared according to the four TMITs. The proportions of TMIT I, defined by high PD-L1 and CD8A expression, were high in lung adenocarcinoma (67.1%) and kidney clear cell carcinoma (64.8%) among solid cancers. The number of somatic mutations and the proportion of microsatellite instable-high tumor in TMIT I were significantly higher than those in other TMITs, respectively (P < 0.001). PD-L1 amplification and oncogenic virus infection were significantly associated with TMIT I, respecti...Continue Reading

References

Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·June-Chul LeeDae Seog Heo
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michal MarzecMariusz A Wasik
Mar 4, 2010·International Journal of Cancer. Journal International Du Cancer·Matthias KloorMagnus von Knebel Doeberitz
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
May 16, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin J ChenScott J Rodig
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Jun 25, 2013·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jul 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Caleb RutledgeDaniel J Brat
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Sep 21, 2013·Nature Immunology·Thomas F GajewskiYang-Xin Fu
Oct 3, 2013·Nature Communications·Ka-Wei TangErik Larsson
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeRobert A Anders
Nov 5, 2014·Seminars in Liver Disease·Martin F Sprinzl, Peter R Galle
Nov 28, 2014·Nature·Matthew M GubinRobert D Schreiber
Dec 9, 2014·The New England Journal of Medicine·Stephen M AnsellPhilippe Armand
Feb 16, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A WangG T Liu
Apr 4, 2015·Science·Ton N Schumacher, Robert D Schreiber
Apr 17, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Inge C van GoolDavid N Church
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Apr 22, 2015·The New England Journal of Medicine·Edward B GaronUNKNOWN KEYNOTE-001 Investigators
May 16, 2015·Cancer Research·Michele W L TengMark J Smyth
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Jul 29, 2015·Frontiers in Oncology·Powell Perng, Michael Lim

❮ Previous
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Citations

Aug 27, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marius IliePaul Hofman
Oct 28, 2016·The Journal of Investigative Dermatology·Marcella TazzariChiara Castelli
Nov 10, 2016·Vaccines·Soumaya KarakiEric Tartour
Mar 23, 2017·Pharmacology & Therapeutics·Jason Lohmueller, Olivera J Finn
May 4, 2017·Expert Review of Respiratory Medicine·Chiara LazzariMariacarmela Santarpia
Apr 28, 2017·Expert Opinion on Biological Therapy·Mariela A Moreno AyalaMarianela Candolfi
Jul 26, 2017·Nature Reviews. Clinical Oncology·Wolf H FridmanGuido Kroemer
Nov 5, 2017·Cold Spring Harbor Perspectives in Medicine·Semini Sumanasuriya, Johann De Bono
Feb 3, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Takayuki Nakayama, Shigehisa Kitano
Mar 13, 2019·Immunotherapy·Yue SongMingzhi Zhang
Mar 22, 2019·Andrology·J T LafinJ F Amatruda
May 8, 2020·Bioscience Reports·Xiaodong ChenYugong Feng
Dec 3, 2016·The Journal of Experimental Medicine·Antoni Ribas, Siwen Hu-Lieskovan
Sep 19, 2018·Scientific Reports·Young Hwan ChangKyoung-Mee Kim
Dec 1, 2019·International Journal of Environmental Research and Public Health·Cheng-Hsueh LeeBo-Ying Bao
Oct 21, 2017·Nature Communications·Chan-Young OckJu-Seog Lee
Oct 31, 2019·Journal of Oncology·Lucía Figueroa-ProttiWarner Alpízar-Alpízar
Aug 20, 2020·Breast Cancer Research : BCR·Xue ChaoJingping Yun

❮ Previous
Next ❯

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