Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation

Gut
G L LyfordG Farrugia

Abstract

Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation. The aims of this study were to determine the normal distribution of ICC within the human colon and to determine if ICC are decreased throughout the colon in slow transit constipation. The caecum, ascending, transverse, and sigmoid colons from six patients with slow transit constipation and colonic tissue from patients with resected colon cancer were used for this study. ICC cells were identified with a polyclonal antibody to c-Kit, serial 0.5 microm sections were obtained by confocal microscopy, and three dimensional software was employed to reconstruct the entire thickness of the colonic muscularis propria and submucosa. ICC were located within both the longitudinal and circular muscle layers. Two networks of ICC were identified, one in the myenteric plexus region and another, less defined network, in the submucosal border. Caecum, ascending colon, transverse colon, and sigmoid colon displayed similar ICC volumes. ICC volume was significantly lower in the slow transit constipation patients across all colonic regions. The data s...Continue Reading

References

Dec 1, 1990·Community Outlook·P Keating
Jan 1, 1989·Neuroscience·J A Kiernan, E A Heinicke
Jan 1, 1996·Diseases of the Colon and Rectum·D Z LubowskiD W King
Oct 1, 1996·Gastroenterology·J M VanderwindenJ J Vanderhaeghen
Mar 1, 1997·Diseases of the Colon and Rectum·D C NyamD M Rath
Jul 14, 1998·Nature Medicine·L ThomsenJ D Huizinga
Nov 24, 1999·Annals of Surgery·C H KnowlesP J Lunniss
Dec 22, 1999·Microscopy Research and Technique·J M Vanderwinden, J J Rumessen
Apr 1, 2000·Journal of the Autonomic Nervous System·R HaggerD Kumar
Jan 9, 2001·The Anatomical Record·S M Ward, K M Sanders
Mar 3, 2001·Diseases of the Colon and Rectum·A J PikarskyS D Wexner

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Citations

Feb 3, 2011·Pediatric Surgery International·Yee Ian YikBridget R Southwell
Feb 3, 2005·International Journal of Colorectal Disease·Wei-Dong TongSheng-Ben Zhang
Oct 19, 2005·International Journal of Colorectal Disease·Jeffrey TomanSusan Galandiuk
Aug 26, 2009·International Journal of Colorectal Disease·Seyed Alireza TaghaviAmir Ahmad Mostaghni
Jun 10, 2009·Cell and Tissue Research·Jüri Johannes RumessenThomas Horn
Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·Gabrio BassottiBruno Salerni
Jun 2, 2007·Journal of Molecular Histology·Mihail E HinescuLaurentziu M Popescu
Aug 8, 2006·Current Gastroenterology Reports·Lucinda A HarrisMichael D Crowell
Dec 31, 2003·Journal of the American College of Surgeons·Robert D Madoff, Sharon L Dykes
Mar 8, 2005·Journal of Pediatric Surgery·Sebastian K KingJohn M Hutson
Feb 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gabrio BassottiBruno Salerni
May 1, 2005·Clinics in Colon and Rectal Surgery·Matthew D Vrees, Eric G Weiss
May 1, 2008·Clinics in Colon and Rectal Surgery·Jared C Frattini, Juan J Nogueras
Mar 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Ariel E FeldsteinGianrico Farrugia
Feb 8, 2006·Current Opinion in Gastroenterology·Michael P Jones, Sarah Wessinger
Feb 28, 2007·The American Journal of Surgical Pathology·Guido IantornoVincenzo Villanacci
May 8, 2008·The American Journal of Surgical Pathology·Lai Mun WangKieran Sheahan
Mar 3, 2009·The American Journal of Surgical Pathology·Aurelien AmiotBernard Messing
Jun 28, 2013·Journal of the Royal Society, Interface·Jerry GaoLeo K Cheng
Jan 27, 2005·Journal of Paediatrics and Child Health·B R SouthwellJ M Hutson
Feb 27, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Gabrio BassottiBruno Salerni
Oct 1, 2004·ANZ Journal of Surgery·Sebastian K KingBridget R Southwell
Jun 11, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C J O'DeaD A Wattchow
Aug 30, 2005·Journal of Clinical Pathology·G BassottiV Villanacci
Apr 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pedro J Gomez-PinillaGianrico Farrugia
Mar 17, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuan-An LiuShiue-Cheng Tang
Jun 2, 2012·Cells, Tissues, Organs·Goran Radenkovic, Mirjana Abramovic
Dec 8, 2010·Critical Reviews in Biomedical Engineering·Peng DuAndrew J Pullan
Jan 10, 2009·World Journal of Gastroenterology : WJG·Charles H Knowles, Joanne E Martin
Jul 9, 2010·World Journal of Gastroenterology : WJG·Randa-M MostafaHosam Hamdy
Sep 8, 2010·World Journal of Gastroenterology : WJG·Christian BreuerRüdiger Adam
Apr 20, 2013·World Journal of Gastroenterology : WJG·Liang-Liang ShiXiao-Ping Zou
Jul 19, 2013·World Journal of Gastroenterology : WJG·Gabrio BassottiGabriel Becheanu
May 31, 2013·The Onderstepoort Journal of Veterinary Research·Colin Musara, Camille Vaillant
Jan 15, 2014·Cell and Tissue Research·Mirjana AbramovicAleksandra Velickov
Aug 17, 2012·Virchows Archiv : an International Journal of Pathology·Sheila Jorge AdadAlessandro Adad Jammal
May 11, 2004·International Journal of Colorectal Disease·Innocenzo SammarcoRaffaele Geremia
Aug 19, 2008·Journal of Gastroenterology·Yasushi AdachiYasuo Kato
Apr 8, 2006·Gynecologic and Obstetric Investigation·G HutchingsD De Ridder
Mar 27, 2007·Digestive Diseases and Sciences·Ana Cristina Hernando-HarderHermann Harder
Nov 22, 2007·Digestive Diseases and Sciences·Arman KilicMatthew J Schuchert

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