Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation

G L LyfordG Farrugia


Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation. The aims of this study were to determine the normal distribution of ICC within the human colon and to determine if ICC are decreased throughout the colon in slow transit constipation. The caecum, ascending, transverse, and sigmoid colons from six patients with slow transit constipation and colonic tissue from patients with resected colon cancer were used for this study. ICC cells were identified with a polyclonal antibody to c-Kit, serial 0.5 microm sections were obtained by confocal microscopy, and three dimensional software was employed to reconstruct the entire thickness of the colonic muscularis propria and submucosa. ICC were located within both the longitudinal and circular muscle layers. Two networks of ICC were identified, one in the myenteric plexus region and another, less defined network, in the submucosal border. Caecum, ascending colon, transverse colon, and sigmoid colon displayed similar ICC volumes. ICC volume was significantly lower in the slow transit constipation patients across all colonic regions. The data s...Continue Reading


Dec 1, 1990·Community Outlook·P Keating
Jan 1, 1989·Neuroscience·J A Kiernan, E A Heinicke
Jan 1, 1996·Diseases of the Colon and Rectum·D Z LubowskiD W King
Oct 1, 1996·Gastroenterology·J M VanderwindenJ J Vanderhaeghen
Mar 1, 1997·Diseases of the Colon and Rectum·D C NyamD M Rath
Jul 14, 1998·Nature Medicine·L ThomsenJ D Huizinga
Nov 24, 1999·Annals of Surgery·C H KnowlesP J Lunniss
Dec 22, 1999·Microscopy Research and Technique·J M Vanderwinden, J J Rumessen
Apr 1, 2000·Journal of the Autonomic Nervous System·R HaggerD Kumar
Jan 9, 2001·The Anatomical Record·S M Ward, K M Sanders
Mar 3, 2001·Diseases of the Colon and Rectum·A J PikarskyS D Wexner

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