Pan-genome Analysis of Ancient and Modern Salmonella enterica Demonstrates Genomic Stability of the Invasive Para C Lineage for Millennia.

Current Biology : CB
Zhemin ZhouMark Achtman

Abstract

Salmonella enterica serovar Paratyphi C causes enteric (paratyphoid) fever in humans. Its presentation can range from asymptomatic infections of the blood stream to gastrointestinal or urinary tract infection or even a fatal septicemia [1]. Paratyphi C is very rare in Europe and North America except for occasional travelers from South and East Asia or Africa, where the disease is more common [2, 3]. However, early 20th-century observations in Eastern Europe [3, 4] suggest that Paratyphi C enteric fever may once have had a wide-ranging impact on human societies. Here, we describe a draft Paratyphi C genome (Ragna) recovered from the 800-year-old skeleton (SK152) of a young woman in Trondheim, Norway. Paratyphi C sequences were recovered from her teeth and bones, suggesting that she died of enteric fever and demonstrating that these bacteria have long caused invasive salmonellosis in Europeans. Comparative analyses against modern Salmonella genome sequences revealed that Paratyphi C is a clade within the Para C lineage, which also includes serovars Choleraesuis, Typhisuis, and Lomita. Although Paratyphi C only infects humans, Choleraesuis causes septicemia in pigs and boar [5] (and occasionally humans), and Typhisuis causes epide...Continue Reading

Citations

May 17, 2019·Journal of Clinical Microbiology·Rebecca J Bennett, Kate S Baker
May 30, 2019·BMC Genomics·Alexey V RakovDieter M Schifferli
May 30, 2020·Molecular Biology and Evolution·Jaelle C BrealeyKaterina Guschanski
Apr 7, 2019·Nature Reviews. Genetics·Maria A SpyrouJohannes Krause
Feb 26, 2020·Nature Ecology & Evolution·Anne C Stone
Jul 10, 2019·Annual Review of Microbiology·Kirsten I BosJohannes Krause
Jun 20, 2020·Science·Simon Y W Ho, Sebastián Duchêne
Feb 26, 2020·Nature Ecology & Evolution·Felix M KeyJohannes Krause
Apr 14, 2020·Algorithms for Molecular Biology : AMB·Roland Wittler
Oct 6, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark Achtman, Zhemin Zhou
Jul 1, 2020·Microbial Genomics·Nicolas Arning, Daniel J Wilson
Dec 16, 2019·Microbes and Infection·Sophia Häfner
Oct 16, 2020·Genome Research·Zhemin ZhouMark Achtman
Feb 24, 2021·Wellcome Open Research·Mark AchtmanSéamus Fanning
Jun 17, 2021·Bioinformatics·Andreas Rempel, Roland Wittler
Aug 3, 2021·Frontiers in Immunology·Magdalena HallerBen Krause-Kyora
Oct 7, 2020·Current Biology : CB·Sebastián DuchêneHendrik Poinar

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Datasets Mentioned

BETA
PRJEB19916

Methods Mentioned

BETA
Deamination
chips
ICEs
chip
PCR
Assay

Software Mentioned

ParaC Pan - genome
SAMtools
PHASTER
TRIMAL
MGPlacer
BBmerge
II
MAFFT
R function ACE ( Ancestral Character Estimation )
Interactive

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