PAN RNA: transcriptional exhaust from a viral engine

Journal of Biomedical Science
Mel Campbell, Yoshihiro Izumiya

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi's sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Castleman's disease. KSHV genomes are maintained as episomes within infected cells and the virus exhibits a biphasic life cycle consisting of a life-long latent phase during which only a few viral genes are expressed and no viral progeny are produced and a transient lytic reactivation phase, in which a full repertoire of ~ 80 lytic genes are activated in a temporally regulated manner culminating in the release of new virions. Lytic replication is initiated by a single viral protein, K-Rta (ORF50), which activates more than 80 viral genes from multiple resident viral episomes (i.e., viral chromosomes). One of the major targets of K-Rta is a long non-coding nuclear RNA, PAN RNA (polyadenylated nuclear RNA), a lncRNA that accumulates to exceedingly high levels in the nucleus during viral reactivation. K-Rta directly binds to the PAN RNA promoter and robustly activates PAN RNA expression. Although PAN RNA has been known for over 20 years, its role in viral replication is still incompletely understood. In this perspective, we will...Continue Reading

References

Jan 1, 1990·Molecular and Cellular Biology·C I BrannanS M Tilghman
Feb 1, 1995·Journal of Virology·R H Sadler, N Raab-Traub
Jan 26, 1996·Cell·G Dieci, A Sentenac
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·W ZhongD Ganem
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·R SunG Miller
May 4, 2002·Science·Philipp KapranovThomas R Gingeras
Aug 18, 2004·Nature Genetics·Justin M O'SullivanNick J Proudfoot
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xuezhong CaiBryan R Cullen
Jul 30, 2005·Journal of Virology·Jill BechtelDon Ganem
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Dec 2, 2005·Genes & Development·Athar Ansari, Michael Hampsey
Sep 7, 2007·Molecular Cell·Badri Nath Singh, Michael Hampsey
Mar 21, 2008·The EMBO Journal·Attila NémethGernot Längst
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Rozanne M Sandri-Goldin
Dec 11, 2008·Archives of Virology·Andrew J DavisonEtienne Thiry
Jun 10, 2009·Nature Reviews. Genetics·Heidi Sutherland, Wendy A Bickmore
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Nov 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ilias K NolisDimitris Thanos
Apr 16, 2010·Nature·Tae-Kyung KimMichael E Greenberg
May 21, 2010·PLoS Biology·Francesca De SantaGioacchino Natoli
Jul 28, 2010·PLoS Pathogens·Zsolt TothJae U Jung
Aug 6, 2010·Cell Cycle·James R BoyneAdrian Whitehouse
Dec 22, 2010·Molecular Cell·Jing ZhaoJeannie T Lee
Nov 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Derek GathererAndrew J Davison
Dec 14, 2011·FEMS Microbiology Reviews·Michael P NicollStacey Efstathiou
Dec 20, 2011·Seminars in Cancer Biology·Aron R Marquitz, Nancy Raab-Traub

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Citations

Sep 16, 2020·Non-coding RNA·Alessia GalloPier Giulio Conaldi
Oct 20, 2020·Infectious Agents and Cancer·J CharostadE Faghihloo

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Methods Mentioned

BETA
immunoprecipitation
Hi-C
mmunoprecipitation
transfection
ChIP

Software Mentioned

Volocity®
Velocity

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