Panax Notoginseng Burk attenuates impairment of learning and memory functions and increases ED1, BDNF and beta-secretase immunoreactive cells in chronic stage ischemia-reperfusion injured rats

The American Journal of Chinese Medicine
Chin-Min ChuangJaung-Geng Lin

Abstract

Panax Notoginseng Burk (PN) has been reported to improve blood circulation, as well as learning and memory functions. The purpose of the present study was to investigate the effect of PN on learning and memory functions in chronic cerebral infarct rats. A cerebral infarct animal model was established by blocking the blood flow of both common carotid arteries and right middle cerebral artery for 90 min followed by reperfusion for 4 weeks. PN (0.5 g/kg) was administered orally 3 days per week for 4 weeks, whereas the control group provided bait and water only. The learning and memory functions were estimated by measuring how successful rats were able to negotiate an 8-arm radial maze test; the test was performed after operation once a week for 4 weeks. Finally, the rats were sacrificed and their brains were removed. The brains were sectioned and analyzed for ED1, glial fibrillary acid protein (GFAP), nuclear factor-kappaB, and brain derivative neurotrophin factor (BDNF) and beta-secretase by immunostaining. Cerebral infarct rats given PN were able to successfully navigate the 8-arm radial maze test four weeks after cerebral infarction. PN also increased ED1, BDNF and beta-secretase immunoreactive cells, but did not increase GFAP ...Continue Reading

References

May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Dec 5, 1997·Brain Research. Molecular Brain Research·B ConnorM Dragunow
Oct 7, 1998·Progress in Neurobiology·G StollM Schroeter
Apr 29, 2000·Trends in Pharmacological Sciences·D M Skovronsky, V M Lee
Jan 26, 2002·Journal of Neural Transmission·M Sopala, W Danysz
Mar 22, 2003·Journal of Ethnopharmacology·Qing Fang XuDao Feng Chen
Dec 23, 2003·Journal of Neuroscience Methods·Ricardo Alexandre PaganelliHumberto Milani
Jan 24, 2006·Journal of Ethnopharmacology·Ava RhuleDavid M Shepherd
Feb 3, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Keila M CeresérJoão Quevedo
Apr 25, 2006·Brain Research·Edward A M DuckworthKeith R Pennypacker
Jul 22, 2006·Brain Research·Chun-Hua HangJing-Song Li
Sep 26, 2006·Biochemical Pharmacology·Sylvie Mémet
Dec 19, 2006·Neurobiology of Aging·J A JohnstonA P Passmore

❮ Previous
Next ❯

Citations

Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eun Bok BaekSung Joon Kim
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ryszard PlutaMirosław Jabłoński
May 6, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Mar 5, 2016·Pharmacological Reports : PR·Marzena Ułamek-KoziołStanisław J Czuczwar
Jan 25, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Dennis ChangAlan Bensoussan
Mar 9, 2021·Frontiers in Aging Neuroscience·Ryszard PlutaStanisław J Czuczwar
Jul 23, 2011·Physiological Research·M JabłońskiR Pluta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.