Abstract
Panax Notoginseng Burk (PN) has been reported to improve blood circulation, as well as learning and memory functions. The purpose of the present study was to investigate the effect of PN on learning and memory functions in chronic cerebral infarct rats. A cerebral infarct animal model was established by blocking the blood flow of both common carotid arteries and right middle cerebral artery for 90 min followed by reperfusion for 4 weeks. PN (0.5 g/kg) was administered orally 3 days per week for 4 weeks, whereas the control group provided bait and water only. The learning and memory functions were estimated by measuring how successful rats were able to negotiate an 8-arm radial maze test; the test was performed after operation once a week for 4 weeks. Finally, the rats were sacrificed and their brains were removed. The brains were sectioned and analyzed for ED1, glial fibrillary acid protein (GFAP), nuclear factor-kappaB, and brain derivative neurotrophin factor (BDNF) and beta-secretase by immunostaining. Cerebral infarct rats given PN were able to successfully navigate the 8-arm radial maze test four weeks after cerebral infarction. PN also increased ED1, BDNF and beta-secretase immunoreactive cells, but did not increase GFAP ...Continue Reading
References
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Mar 11, 1983·Science·J T CoyleM R DeLong
Sep 23, 1996·Brain Research·H KatoY Itoyama
Jan 9, 1997·Brain Research·Z ZhangC Powers
Dec 5, 1997·Brain Research. Molecular Brain Research·B ConnorM Dragunow
Oct 7, 1998·Progress in Neurobiology·G StollM Schroeter
Apr 29, 2000·Trends in Pharmacological Sciences·D M Skovronsky, V M Lee
Jun 19, 2001·Neuroscience Letters·L R ZhaoZ Kokaia
Oct 10, 2001·Neurology·H HénonD Leys
Jan 26, 2002·Journal of Neural Transmission·M Sopala, W Danysz
Mar 22, 2003·Journal of Ethnopharmacology·Qing Fang XuDao Feng Chen
Dec 23, 2003·Journal of Neuroscience Methods·Ricardo Alexandre PaganelliHumberto Milani
May 4, 2004·Brain Research·Yi WenJames W Simpkins
Aug 26, 2004·Brain Research·Yuko YasudaSetsuya Fujita
Dec 6, 2005·Brain Research·Tetsuya MizunoAkio Suzumura
Jan 24, 2006·Journal of Ethnopharmacology·Ava RhuleDavid M Shepherd
Feb 3, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Keila M CeresérJoão Quevedo
Feb 7, 2006·Journal of Ethnopharmacology·Ching-Liang HsiehNou-Ying Tang
Apr 20, 2006·Behavioural Brain Research·Teresita L BrionesMai Nguyen
Apr 25, 2006·Brain Research·Edward A M DuckworthKeith R Pennypacker
May 2, 2006·Brain, Behavior, and Immunity·Matthew G FrankSteven F Maier
Jul 18, 2006·Neuroscience·Y HayashiH Nakanishi
Jul 22, 2006·Brain Research·Chun-Hua HangJing-Song Li
Aug 4, 2006·Brain Research·Yun Zhang, William M Pardridge
Aug 15, 2006·Neurobiology of Aging·M NistorE Head
Sep 26, 2006·Biochemical Pharmacology·Sylvie Mémet
Dec 19, 2006·Neurobiology of Aging·J A JohnstonA P Passmore
Citations
Dec 3, 2009·Journal of Molecular Neuroscience : MN·Fei WangYan Cheng
Oct 20, 2012·Molecular Neurobiology·Ryszard PlutaMirosław Jabłoński
Mar 23, 2013·Molecular Neurobiology·Ryszard PlutaStanisław J Czuczwar
Oct 30, 2010·Chinese Medicine·Roy Chi-Yan ChoiKarl Wah-Keung Tsim
May 30, 2013·Journal of Ginseng Research·Hee Jin KimChan Young Shin
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Kai SunJingyan Han
Jul 15, 2016·Fundamental & Clinical Pharmacology·Shuyong Wei
Feb 4, 2010·The American Journal of Chinese Medicine·Nou-Ying TangChing-Liang Hsieh
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eun Bok BaekSung Joon Kim
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ryszard PlutaMirosław Jabłoński
Apr 17, 2015·Neural Regeneration Research·Peiman AlesheikhYan-Shu Pan
Mar 8, 2018·Molecular Medicine Reports·Yonglai ZhangNaibao Zhou
Oct 1, 2017·Experimental and Therapeutic Medicine·Ruhui LinLidian Chen
May 6, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Mar 5, 2016·Pharmacological Reports : PR·Marzena Ułamek-KoziołStanisław J Czuczwar
Jan 25, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Dennis ChangAlan Bensoussan
Oct 19, 2013·Experimental and Therapeutic Medicine·Yu WangLei Li
Mar 9, 2021·Frontiers in Aging Neuroscience·Ryszard PlutaStanisław J Czuczwar
Jul 23, 2011·Physiological Research·M JabłońskiR Pluta