Panax notoginseng saponins ameliorate impaired arterial vasodilation in SHRSP.Z-Lepr(fa) /lzmDmcr rats with metabolic syndrome

Clinical and Experimental Pharmacology & Physiology
Ting WuKazumasa Shinozuka

Abstract

Panax notoginseng saponins (PNS) are major components of Panax notoginseng, a herb with established clinical efficacy against vascular diseases. SHRSP.Z-Lepr(fa) /IzmDmcr (SHRSP.ZF) rats, a new animal model for metabolic syndrome, display an impaired vasorelaxation response in aortas and mesenteric arteries that is mediated by nitric oxide (NO). This study investigated whether PNS and its components can ameliorate this vascular dysfunction in SHRSP.ZF rats. In an in vitro study, in the presence or absence of PNS and its components, vasodilation in response to nitroprusside was determined from myographs under isometric tension conditions in aortas and mesenteric arteries from male SHRSP.ZF rats at 18-20 weeks of age. In an in vivo study, PNS (30 mg/kg per day) was orally administered to SHRSP.ZF rats from 8 to 20 weeks of age. In vitro treatment with PNS and Ginsenoside Rb1 increased nitroprusside-induced relaxation of aortas and mesenteric arteries in SHRSP.ZF rats. The PNS-induced increase was not affected by a nitric oxide (NO) synthase inhibitor or endothelium denudation. Relaxation in response to a cell-permeable cGMP analogue was increased by PNS, but cGMP accumulation by nitroprusside was not altered. In vivo treatment wi...Continue Reading

References

Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Junko Hiraoka-YamamotoKatsumi Ikeda
Jul 29, 2005·The Proceedings of the Nutrition Society·D I ShawC M Williams
Jan 24, 2006·American Journal of Therapeutics·Suneetha Venkatapuram, Richard P Shannon
Aug 2, 2006·Biological & Pharmaceutical Bulletin·Yoko KubotaKazumasa Shinozuka
Dec 16, 2006·The Journal of Clinical Hypertension·Leopoldo Raij
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takahiro UenoYukio Yamori
Feb 13, 2009·International Journal of Molecular Medicine·Takahiro UenoYukio Yamori
Aug 18, 2009·Molecular and Cellular Endocrinology·E Maury, S M Brichard
Jul 28, 2010·Clinical and Experimental Pharmacology & Physiology·Satomi KagotaKazumasa Shinozuka
Aug 6, 2010·Biological & Pharmaceutical Bulletin·Ya LiuXiao-Hui Li
Dec 9, 2010·Biological & Pharmaceutical Bulletin·Yukari TadaKazumasa Shinozuka
Dec 27, 2012·Clinical and Experimental Nephrology·Fumihiro SugiyamaToshihiko Ishimitsu
Apr 11, 2013·Microvascular Research·Satomi KagotaKazumasa Shinozuka
Oct 2, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ya LiuXiaohui Li
Feb 4, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaochen YangJie Wang
Apr 26, 2014·Current Atherosclerosis Reports·Teresa StrisciuglioGennaro Galasso
Aug 26, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaochen YangJie Wang
Feb 5, 2015·The Journal of Surgical Research·Xiao-Hong LinLiang-Long Chen

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Citations

Mar 31, 2017·Metabolic Syndrome and Related Disorders·Satomi KagotaKazumasa Shinozuka
Oct 25, 2016·BioFactors·Ekaterina Vladimirovna Fomenko, Yuling Chi
May 18, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bin Rui YangSimon Ming-Yuen Lee
May 25, 2021·Journal of Ginseng Research·Sang Jun YoonKi Tae Suk

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