PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression

Circulation. Arrhythmia and Electrophysiology
Shamone R Gore-PanterJonathan D Smith

Abstract

Genome-wide studies reveal that genetic variants at chromosome 4q25 constitute the strongest locus associated with atrial fibrillation, the most frequent arrhythmia. However, the mechanisms underlying this association are unknown. Our goal is to find and characterize left atrial-expressed transcripts in the chromosome 4q25 atrial fibrillation risk locus that may play a role in atrial fibrillation pathogenesis. RNA sequencing performed on human left/right pairs identified an intergenic long noncoding RNA adjacent to the PITX2 gene, which we have named PANCR (PITX2 adjacent noncoding RNA). In a human tissue screen, PANCR was expressed specifically in the left atria and eye and in no other chambers of the heart. The levels of PANCR and PITX2c RNAs were highly correlated in 233 human left atrial appendage samples. PANCR levels were not associated with either atrial rhythm status or the genotypes of the chromosome 4q25 atrial fibrillation risk variants. Both PANCR and PITX2c RNAs were induced early during differentiation of human embryonic stem cells into cardiomyocytes. Because long noncoding RNAs often control gene expression, we performed siRNA-mediated knockdown of PANCR, and this treatment repressed PITX2c expression and mimick...Continue Reading

References

May 15, 2002·Cell·Sean R Eddy
Aug 18, 2004·Circulation·Donald M Lloyd-JonesEmelia J Benjamin
Jul 3, 2007·Nature·Daniel F GudbjartssonKari Stefansson
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Nov 11, 2008·Nucleic Acids Research·Feifei XiaoTongbin Li
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Feb 23, 2010·Nature Genetics·Patrick T EllinorStefan Kääb
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jun WangJames F Martin
May 13, 2010·Development·Dekker C DeaconCaroline E Burns
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Sep 28, 2010·Mechanisms of Development·Kota Y MiyasakaToshihiko Ogura
May 10, 2011·Trends in Cell Biology·Orly Wapinski, Howard Y Chang
Aug 30, 2011·Nature·Mitchell GuttmanEric S Lander
Apr 5, 2012·Circulation. Cardiovascular Genetics·Jeffrey HsuJonathan D Smith
May 1, 2012·Nature Genetics·Patrick T EllinorStefan Kääb
Jun 6, 2012·Annual Review of Biochemistry·John L Rinn, Howard Y Chang
Jun 16, 2012·International Journal of Immunopathology and Pharmacology·G D NorataA L Catapano
Sep 8, 2012·Genome Research·Balázs BánfaiLeonard Lipovich
Oct 30, 2012·Circulation Research·Nicole SchonrockJohn S Mattick
Jan 29, 2013·Cell·Carla A KlattenhoffLaurie A Boyer
Aug 21, 2013·Trends in Cardiovascular Medicine·Diego FrancoMarina Campione
Nov 5, 2013·Biochimica Et Biophysica Acta·Per JohnssonKevin V Morris
Jan 28, 2014·Nature·Anamaria NecsuleaHenrik Kaessmann
Feb 4, 2014·Journal of the American College of Cardiology·Steven A LubitzPatrick T Ellinor
Feb 22, 2014·Circulation Research·Kun WangPei-Feng Li
Mar 1, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert D BellJoseph M Miano
Mar 8, 2014·Circulation Research·Katharina M MichalikStefanie Dimmeler
Mar 26, 2014·Circulation Research·Regalla KumarswamyThomas Thum
May 16, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Thomas Thum, Regalla Kumarswamy
Jun 16, 2015·Journal of Molecular and Cellular Cardiology·Ruairidh I R MartinBernard D Keavney

❮ Previous
Next ❯

Citations

May 4, 2016·Current Cardiology Reports·Alejandra Gutierrez, Mina K Chung
Oct 22, 2016·Journal of the American College of Cardiology·Fahima SyedaPaulus Kirchhof
Feb 22, 2017·The Journal of Physiology·Fahima SyedaLarissa Fabritz
Apr 13, 2018·Cardiovascular Research·Scott BarichelloZachary Laksman
Mar 3, 2018·Circulation Research·Jordi HeijmanStanley Nattel
Jan 20, 2016·Circulation. Arrhythmia and Electrophysiology·Andrew P Holmes, Paulus Kirchhof
Mar 4, 2020·Molecular and Cellular Biochemistry·Isabela Tiemy PereiraBruno Dallagiovanna
May 14, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexander T Mikhailov, Mario Torrado
Aug 6, 2020·International Journal of Molecular Sciences·Emre BektikDa-Zhi Wang
Aug 26, 2020·JCI Insight·Catherine E LipovskyStacey L Rentschler
Mar 23, 2019·Heart Failure Reviews·Abdel Rahman Yousry Afify
Apr 4, 2020·Journal of Biomedical Science·Chih-Fan YehKai-Chien Yang
Nov 25, 2016·Frontiers in Cell and Developmental Biology·Stefan FrankLeo Kurian
Oct 9, 2019·Journal of Zhejiang University. Science. B·Gui-Zhen ZhengZhi-Yong Liu
Feb 3, 2019·Non-coding RNA·Shrey GandhiMonika Stoll
Nov 5, 2019·Frontiers in Cell and Developmental Biology·Sweta SwetaRaghu Bhushan
May 19, 2021·Pflügers Archiv : European journal of physiology·Wenli DaiChristopher R Weber
Sep 18, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yuling ZhouYan Wang
Sep 18, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carlos Pulido-Quetglas, Rory Johnson
Dec 4, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carlos García-PadillaDiego Franco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.