Pancreas and islet transplants for patients with diabetes: taking positions and making decisions.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
R P Robertson

Abstract

To help endocrinologists develop a position and then make decisions about the applicability of pancreas and islet transplantations for treatment of patients with diabetes. An overview is provided of peer-reviewed literature reporting clinical outcomes of pancreas and islet transplantations, emphasizing rates of success, effect on metabolic regulation and secondary complications, and changes in the quality of life. Pancreas transplantation-related patient survival rates correspond generally to survival rates of similar patients who have not undergone transplantation, and organ survival rates are consistent with rates of other commonly transplanted organs. Beneficial effects include normalization of glycemia; restoration of glucagon, epinephrine, and symptom responses to hypoglycemia; stabilization of renal and neural complications; and improvement in the quality of life. Autoislet transplantation is commonly successful in preventing diabetes attributable to pancreatectomy for chronic pancreatitis. The success rates associated with alloislet transplantation remain low. Pancreas transplantation is a therapeutic, not an experimental, option that should be considered when patients with diabetes are candidates for kidney transplantat...Continue Reading

References

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Citations

Oct 18, 2008·Diabetes, Obesity & Metabolism·Z Medarova, A Moore
Nov 2, 2005·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·H OzdenO Alatas
Jul 31, 2013·Nature Reviews. Endocrinology·Rainer W G Gruessner, Angelika C Gruessner
Dec 17, 2009·Current Opinion in Organ Transplantation·Chiara GremizziAntonio Secchi
May 26, 2009·Lancet·Steve A WhiteDavid E R Sutherland

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